Parsyan Armen, Kochiyanil Arpitha, Bonvissuto Anne C, Bhat Vasudeva, Allan Alison L
Department of Anatomy and Cell Biology, Schulich School of Medicine & Dentistry, Western University, London, ON N6A 5C1, Canada.
Verspeeten Family Cancer Centre, London Health Sciences Centre and London Health Sciences Centre Research Institute, London, ON N6A 5W9, Canada.
Biomedicines. 2025 Jun 11;13(6):1435. doi: 10.3390/biomedicines13061435.
Interferon (IFN)-induced proteins with tetratricopeptide repeats (IFITs) are key interferon-stimulated genes (ISGs), and in humans include IFIT1, IFIT2, IFIT3 and IFIT5. These proteins are primarily known for their role in the innate immune response to pathogens. However, growing evidence suggests that IFITs participate in a range of other cellular processes, including cancer development and progression. Notably, IFITs may behave in either a pro-oncogenic or tumor suppressive fashion depending on cancer types and emphasizing their potential dual function in tumorigenesis. Importantly, IFITs have shown potential to be utilized as clinical biomarkers in oncology. Their aberrant expression has been correlated with survival and other clinical outcomes, including resistance to radiotherapy, chemotherapy, targeted treatments and immunotherapy in various cancers. Additionally, they have also been reported to be a part of various clinical predictive models in cancers. This review provides an overview of the current understanding of IFIT proteins' involvement in cancers, with an emphasis on their emerging roles as clinically relevant biomarkers.
含四肽重复序列的干扰素（IFN）诱导蛋白（IFITs）是关键的干扰素刺激基因（ISGs），在人类中包括IFIT1、IFIT2、IFIT3和IFIT5。这些蛋白主要因其在对病原体的固有免疫反应中的作用而闻名。然而，越来越多的证据表明，IFITs参与一系列其他细胞过程，包括癌症的发生和发展。值得注意的是，根据癌症类型，IFITs可能表现出促癌或抑癌作用，这突出了它们在肿瘤发生中的潜在双重功能。重要的是，IFITs已显示出作为肿瘤学临床生物标志物的潜力。它们的异常表达与生存及其他临床结果相关，包括在各种癌症中对放疗、化疗、靶向治疗和免疫治疗的抗性。此外，据报道它们也是癌症各种临床预测模型的一部分。本综述概述了目前对IFIT蛋白参与癌症的理解，重点是它们作为临床相关生物标志物的新作用。
