Zhao Yan, Tang Fangli, Shi Yunlong, Tan Qinyu, Ju Qingxin, Yang Ziyi, Yang Guanqing, Gao Pengfei, Kim Sung Woo, Xi Lin, Cao Guoqing, Li Bugao
College of Animal Science, Shanxi Agricultural University, Jinzhong 030801, China.
Jinzhong City Taigu District Modern Agricultural Industrial Development Center, Jinzhong 030800, China.
Animals (Basel). 2025 Jun 19;15(12):1813. doi: 10.3390/ani15121813.
This study investigated the effects of dietary niacinamide supplementation on blood parameters, antioxidant status, and intestinal health in finishing pigs fed low-protein diets. Sixty-four pigs (Duroc × Landrace × Yorkshire; 80.4 ± 0.1 kg) were randomly allocated to four dietary treatments supplemented with 30 (NAM30), 130 (NAM130), 230 (NAM230), and 330 (NAM330) mg/kg niacinamide for 30 days. Each treatment had four replicate pens and four pigs per pen. Growth performance was not significantly affected. However, the NAM130 group showed higher ( < 0.05) hemoglobin levels, reduced ( < 0.05) serum malondialdehyde and interleukin-1β (IL-1β) concentrations, and altered intestinal microbiota composition, including lower abundance ( < 0.05). Serum alanine aminotransferase levels increased quadratically ( < 0.05) with niacinamide supplementation, with a breakpoint at approximately 221 mg/kg. These results suggest that dietary supplementation with 130 mg/kg niacinamide improves antioxidant status, modulates inflammation, and supports intestinal microbial balance, with a safety threshold to avoid hepatic stress.
本研究调查了在低蛋白日粮育肥猪中补充膳食烟酰胺对血液参数、抗氧化状态和肠道健康的影响。将64头猪（杜洛克×长白×大白；80.4±0.1千克）随机分配到四种日粮处理组，分别补充30（NAM30）、130（NAM130）、230（NAM230）和330（NAM330）毫克/千克烟酰胺，为期30天。每个处理组有四个重复栏，每栏四头猪。生长性能未受到显著影响。然而，NAM130组的血红蛋白水平较高（<0.05），血清丙二醛和白细胞介素-1β（IL-1β）浓度降低（<0.05），肠道微生物群组成发生改变，包括丰度较低（<0.05）。随着烟酰胺补充量的增加，血清丙氨酸转氨酶水平呈二次方增加（<0.05），转折点约为221毫克/千克。这些结果表明，补充130毫克/千克烟酰胺可改善抗氧化状态、调节炎症并维持肠道微生物平衡，且有一个避免肝脏应激的安全阈值。
