Dalmer Antonia, Wörner Paul, Manzke Mathias, Gäbel Ralf, Lindner Tobias, Meinel Felix G, Weber Marc-André, David Robert, Lang Cajetan I
Institute of Diagnostic and Interventional Radiology, Paediatric Radiology and Neuroradiology, University Medical Centre Rostock, 18057 Rostock, Germany.
Department of Cardiac Surgery, University Medical Centre Rostock, 18057 Rostock, Germany.
Diagnostics (Basel). 2025 Jun 6;15(12):1447. doi: 10.3390/diagnostics15121447.
: This study aimed to compare changes in functional and strain parameters in young and old mice using cardiac MRI before and shortly after myocardial infarction. : In this prospective experimental study, 7 young mice and 10 old mice underwent a cardiac MRI 5 days before and 2 days after myocardial infarction by LAD ligation. Functional parameters such as EDV, ESV, EF, SV, and Strain were determined. : EDV in the young mice before LAD ligation was significantly lower than in the old mice (-value 0.002). EDV significantly increased after infarction in both groups. ESV was significantly lower in young mice before infarction than in old mice (9.7 ± 2.6 vs. 13.8 ± 3.9 [µL], = 0.029). After infarction, the mean value was still lower but no longer significant. There was no significant difference between young and old mice either before or after infarction for the EF. But again, the decrease was significant for both groups (old: < 0.0001 and young: = 0.0009). Each global strain showed deterioration after infarction. This difference was significant in both subgroups for young mice and old mice for each strain. There were no differences either before or after infarction between the young and old mice. : There were differences in functional parameters between young and old mice in EDV, SV, and CO. Changes in strain parameters in the acute phase post-myocardial infarction did not differ significantly between young and old mice, while there was a clear deterioration in strain parameters after infarction in both groups.
本研究旨在通过心脏磁共振成像（MRI）比较年轻和老年小鼠在心肌梗死前后功能和应变参数的变化。在这项前瞻性实验研究中，7只年轻小鼠和10只老年小鼠在左前降支（LAD）结扎所致心肌梗死前5天和后2天接受了心脏MRI检查。测定了诸如舒张末期容积（EDV）、收缩末期容积（ESV）、射血分数（EF）、每搏输出量（SV）和应变等功能参数。LAD结扎前年轻小鼠的EDV显著低于老年小鼠（P值为0.002）。两组梗死术后EDV均显著增加。梗死前年轻小鼠的ESV显著低于老年小鼠（9.7±2.6 vs. 13.8±3.9 [µL]，P = 0.029）。梗死后，平均值仍较低但不再显著。年轻和老年小鼠梗死前后的EF均无显著差异。但同样，两组的EF下降均显著（老年组：P < 0.0001，年轻组：P = 0.0009）。梗死术后每种整体应变均显示恶化。每种应变在年轻小鼠和老年小鼠的两个亚组中差异均显著。年轻和老年小鼠梗死前后均无差异。年轻和老年小鼠在EDV、SV和心输出量（CO）的功能参数上存在差异。心肌梗死后急性期应变参数的变化在年轻和老年小鼠之间无显著差异，而两组梗死后应变参数均有明显恶化。
