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一种基于分子分层的新型多重诊断算法，用于制定类风湿关节炎的最佳个体化治疗方案。

A Novel Multiplex Diagnostic Algorithm for Developing an Optimal Patient-Tailored Therapy in Rheumatoid Arthritis Based on Molecular Stratification.

作者信息

Margoni Angeliki, Vassiliou Alice G, Papavassiliou Athanasios G

机构信息

Department of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.

First Department of Critical Care Medicine, Evangelismos Hospital, Medical School, National and Kapodistrian University of Athens, 10676 Athens, Greece.

出版信息

Int J Mol Sci. 2025 Jun 12;26(12):5640. doi: 10.3390/ijms26125640.

DOI:10.3390/ijms26125640
PMID:40565104
Abstract

Rheumatoid arthritis (RA) is a progressive and inflammatory autoimmune disease that displays high heterogeneity in etiology, clinical presentation, prognosis, and response to therapy [...].

摘要

类风湿关节炎（RA）是一种进行性炎症性自身免疫性疾病，在病因、临床表现、预后及对治疗的反应方面表现出高度异质性[……]

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Aging (Albany NY). 2024 Jan 16;16(2):1399-1413. doi: 10.18632/aging.205435.
2
Analysis of Enrichment Pathway, Hub Gene, and Protein-Protein Interaction Network in Rheumatoid Arthritis and Construction of Molecular Subtypes in Peripheral Blood.类风湿关节炎中富集通路、枢纽基因及蛋白质-蛋白质相互作用网络分析及其在外周血中的分子亚型构建。
Altern Ther Health Med. 2024 Jan;30(1):134-141.
3
DNA Methylation Signatures of Response to Conventional Synthetic and Biologic Disease-Modifying Antirheumatic Drugs (DMARDs) in Rheumatoid Arthritis.
类风湿关节炎中对传统合成和生物改善病情抗风湿药（DMARDs）反应的DNA甲基化特征
Biomedicines. 2023 Jul 13;11(7):1987. doi: 10.3390/biomedicines11071987.
4
Circulating miRNA-19b as a biomarker of disease progression and treatment response to baricitinib in rheumatoid arthritis patients through miRNA profiling of monocytes.通过对单核细胞的 miRNA 谱分析，循环 miRNA-19b 可作为类风湿关节炎患者疾病进展和巴瑞替尼治疗反应的生物标志物。
Front Immunol. 2023 Mar 28;14:980247. doi: 10.3389/fimmu.2023.980247. eCollection 2023.
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Longitudinal analysis of blood DNA methylation identifies mechanisms of response to tumor necrosis factor inhibitor therapy in rheumatoid arthritis.纵向分析血液 DNA 甲基化可确定类风湿关节炎对肿瘤坏死因子抑制剂治疗反应的机制。
EBioMedicine. 2022 Jun;80:104053. doi: 10.1016/j.ebiom.2022.104053. Epub 2022 May 13.
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