Salman Noor D, Hanker Lars C, Győrffy Balázs, Bartha Áron, Proppe Louisa, Götte Martin
Department of Gynecology and Obstetrics, Münster University Hospital, 48149 Münster, Germany.
Department of Bioinformatics, Semmelweis University, 1085 Budapest, Hungary.
Int J Mol Sci. 2025 Jun 19;26(12):5888. doi: 10.3390/ijms26125888.
The hedgehog pathway is a major regulator of cell growth and differentiation during embryogenesis and early development. The literature suggests that variations in this pathway's genes play a role in tumor progression and response to therapy. This study aimed to assess the correlation between the expression levels of selected genes of this pathway and the progression-free and overall survival of ovarian cancer patients. Using the database Kaplan-Meier plotter, which includes the gene expression and survival data of 1565 ovarian cancer patients, higher expression levels of the genes , , , and displayed better survival correlations, while , , and correlated with adverse outcomes. Further dissection revealed a differential impact of the genes in specific clinical-histopathological categories. Notably, higher expression levels of were associated with a negative impact on ovarian cancer patients under many clinical-histopathological aspects. These results shed new light on the role of these genes in the chemoresponsiveness of ovarian cancer, especially , which could be considered a novel indicator for poor prognosis in epithelial ovarian cancer.
刺猬信号通路是胚胎发生和早期发育过程中细胞生长和分化的主要调节因子。文献表明，该信号通路基因的变异在肿瘤进展和对治疗的反应中起作用。本研究旨在评估该信号通路所选基因的表达水平与卵巢癌患者无进展生存期和总生存期之间的相关性。使用包含1565例卵巢癌患者基因表达和生存数据的Kaplan-Meier plotter数据库，基因 、 、 和 的较高表达水平显示出更好的生存相关性，而 、 和 则与不良预后相关。进一步分析揭示了这些基因在特定临床-组织病理学类别中的不同影响。值得注意的是，在许多临床-组织病理学方面， 的较高表达水平对卵巢癌患者有负面影响。这些结果为这些基因在卵巢癌化疗反应中的作用提供了新的线索，尤其是 ，它可被视为上皮性卵巢癌预后不良的一个新指标。
