Reis-Oliveira Jennifer, Cruz Alex Junio S, Guimarães Nathalia S, Abreu Mauro Henrique N G
Department of Community and Preventive Dentistry, School of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte 31270-800, MG, Brazil.
Department of Nutrition, School of Nursing, Universidade Federal de Minas Gerais, Belo Horizonte 30130-100, MG, Brazil.
Healthcare (Basel). 2025 Jun 6;13(12):1364. doi: 10.3390/healthcare13121364.
Drug interactions (DIs) can alter the effects of medications or result in adverse reactions. This scoping review aimed to map the existing scientific evidence regarding the DI between penicillin and hormonal contraceptives in women. Following the PRISMA-ScR, we conducted electronic searches in the MEDLINE, Embase, Web of Science, and the Virtual Health Library databases from August 2023 to January 2024. Observational studies, monographs, dissertations, theses, and conference abstracts with adolescent, adult, and elderly women who were concurrently using hormonal contraceptives and penicillin were eligible. DIs were defined based on the signs/symptoms presented by the women and self-reported pregnancies. Of the 4023 records identified in the databases, nine studies, published between 1979 and 2021, were included. Variability was found among the studies in terms of sample size, data collection method, participant's age, medication types, diagnostic approach used to confirm the pregnancy, and the author's recommendation of the DI. It could therefore be concluded that while the literature suggests a DI between hormonal contraceptives and penicillin, the level of scientific evidence is still scarce. Additional research on systemic and population factors is essential to better understand this DI and its repercussions.
药物相互作用（DIs）可能会改变药物的效果或导致不良反应。本综述旨在梳理关于女性使用青霉素与激素避孕药之间药物相互作用的现有科学证据。遵循PRISMA-ScR指南，我们于2023年8月至2024年1月在MEDLINE、Embase、科学网和虚拟健康图书馆数据库中进行了电子检索。纳入了针对同时使用激素避孕药和青霉素的青少年、成年和老年女性的观察性研究、专著、学位论文以及会议摘要。根据女性出现的体征/症状和自我报告的妊娠情况来定义药物相互作用。在数据库中识别出的4023条记录中，纳入了1979年至2021年间发表的9项研究。这些研究在样本量、数据收集方法、参与者年龄、药物类型、确认妊娠的诊断方法以及作者对药物相互作用的建议等方面存在差异。因此可以得出结论，虽然文献表明激素避孕药和青霉素之间存在药物相互作用，但科学证据水平仍然不足。对系统因素和人群因素进行更多研究对于更好地理解这种药物相互作用及其影响至关重要。
