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提高对术中诊断挑战的认识以预防误诊和过度治疗:腹腔镜处理酷似卵巢肿瘤的罕见子叶状剥脱性平滑肌瘤

Raising Awareness of Intraoperative Diagnostic Challenges to Prevent Misdiagnosis and Overtreatment: Laparoscopic Management of Rare Cotyledonoid Dissecting Leiomyoma Mimicking Ovarian Tumour.

作者信息

Nguyen Kathy, Rao Tanushree

机构信息

School of Clinical Medicine, Faculty of Medicine and Health, University of New South Wales, Sydney, NSW 2033, Australia.

Minimally Invasive Gynecologic Surgery Unit, Liverpool Hospital, Liverpool, NSW 2170, Australia.

出版信息

Healthcare (Basel). 2025 Jun 6;13(12):1367. doi: 10.3390/healthcare13121367.

DOI:10.3390/healthcare13121367
PMID:40565394
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12192563/
Abstract

Cotyledonoid dissecting leiomyoma (CDL), also known as Sternberg tumour, is a rare variant of leiomyoma that can be easily mistaken for a malignant neoplasm on clinical and radiological examination, posing a diagnostic challenge for clinicians. Although the tumour can extend to neighbouring organs, it typically does not invade them and is considered benign. Therefore, it is essential to recognise and differentiate this leiomyoma variant from other malignancies to avoid misdiagnosis and overtreatment. This report depicts a unique case of CDL misdiagnosed as an ovarian tumour in a woman in her late 50s with post-menopausal bleeding and pelvic pressure. We initially planned and proceeded with a diagnostic laparoscopy and laparoscopic oophorectomy of the right ovarian mass, during which an intraoperative surprise of a retroperitoneal mass was explored and subsequently biopsied. The final histopathology confirmed the presence of the rare fibroid variant CDL. The accompanying surgical video is among the first to feature a laparoscopic surgery of CDL and details the intraoperative findings and laparoscopic resection techniques utilised in this case. Given its rarity and non-specific clinical and radiological findings, diagnosing CDL pre-operatively can be challenging. This case prompts recognition and awareness of CDL and highlights the importance of careful consideration of uncommon differential diagnoses and thorough intraoperative exploration, with the goal of preventing the misdiagnosis and, consequently, overtreatment of unknown masses.

摘要

子叶样解剖性平滑肌瘤(CDL),也称为施特恩贝格瘤,是平滑肌瘤的一种罕见变体,在临床和放射学检查中很容易被误诊为恶性肿瘤,给临床医生带来诊断挑战。尽管肿瘤可延伸至邻近器官,但通常不会侵犯它们,被认为是良性的。因此,识别并将这种平滑肌瘤变体与其他恶性肿瘤区分开来,以避免误诊和过度治疗至关重要。本报告描述了一例独特的CDL病例,该病例发生在一名50多岁绝经后出血并伴有盆腔压迫感的女性身上,最初被误诊为卵巢肿瘤。我们最初计划并进行了诊断性腹腔镜检查及对右侧卵巢肿块的腹腔镜卵巢切除术,在此过程中发现了一个腹膜后肿块并进行了活检。最终的组织病理学检查证实存在罕见的纤维瘤变体CDL。随附的手术视频是最早展示CDL腹腔镜手术的视频之一,详细介绍了该病例的术中发现及所采用的腹腔镜切除技术。鉴于其罕见性以及非特异性的临床和放射学表现,术前诊断CDL具有挑战性。该病例促使人们认识和了解CDL,并强调了仔细考虑罕见鉴别诊断及进行全面术中探查的重要性,目的是防止对不明肿块的误诊以及由此导致的过度治疗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec21/12192563/c6a3a939fe25/healthcare-13-01367-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec21/12192563/79ab0aae0d8d/healthcare-13-01367-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec21/12192563/e606edf893cf/healthcare-13-01367-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec21/12192563/d3bb9b927cf5/healthcare-13-01367-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec21/12192563/c6a3a939fe25/healthcare-13-01367-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec21/12192563/79ab0aae0d8d/healthcare-13-01367-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec21/12192563/e606edf893cf/healthcare-13-01367-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec21/12192563/d3bb9b927cf5/healthcare-13-01367-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec21/12192563/c6a3a939fe25/healthcare-13-01367-g004.jpg

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本文引用的文献

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Int J Surg Pathol. 2025 Aug;33(5):1173-1175. doi: 10.1177/10668969241308200. Epub 2025 Jan 8.
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An Unheard Variant of Leiomyoma Cotyledonoid Dissecting Leiomyoma: Case Report.平滑肌瘤叶状型浸润性平滑肌瘤的一种罕见变体:病例报告
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一例叶状剥脱性平滑肌瘤——腹腔镜活检及促性腺激素释放激素类似物的应用
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Cotyledonoid Dissecting Leiomyoma of the Uterus: A Benign Uterine Tumor That Resembles Malignancy.
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A Case of Cotyledonoid Dissecting Leiomyoma With Associated Disseminated Peritoneal Leiomyomatosis: The Significance of Frozen Section in Identification of This Unusual Entity.1例伴有播散性腹膜平滑肌瘤病的叶状分割性平滑肌瘤病例:冰冻切片在识别这一罕见实体中的意义
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