Bismuth C, Gaultier M, Conso F
Nouv Presse Med. 1977 May 7;6(19):1625-9.
Out of 84 patients with colchicine poisoning hospitalised between 1966 and 1976, 11 died during the first 72 hours. Amongst the 73 survivors, 20 showed signs of marrow aplasia between the 3rd and 6th days, lasting on average 4 days. The average amount of colchicine ingested by these patients was 0.5 to 0.8mg/5g. Marrow aplasia was associated with: -- infectious episodes in all cases, -- haemorrhage in 50%, -- dilution hyponatraemia in 25% (but in 50 % of patients if those in renal failure are excluded), -- regressive polyneuropathy in 10 % of cases, -- secondary alopoecia in all cases, -- weight loss of more than 10 % of initial weight in 60 %. Two patients died as a result of septicaemia. This mortality rate of 10 per cent despite the brief duration of the aplasia and the absence of underlying haematological disease would appear to be related to the susceptibility of these poisoned patients to endogenous secondary infections, essentially intestinal in origin.
在1966年至1976年间住院的84例秋水仙碱中毒患者中，11例在最初72小时内死亡。在73名幸存者中，20例在第3天至第6天出现骨髓再生障碍迹象，平均持续4天。这些患者摄入秋水仙碱的平均量为0.5至0.8mg/5g。骨髓再生障碍与以下情况相关：——所有病例均有感染发作，——50%有出血，——25%有稀释性低钠血症（但排除肾衰竭患者后，50%的患者有此情况），——10%的病例有退行性多神经病，——所有病例均有继发性脱发，——60%体重减轻超过初始体重的10%。两名患者死于败血症。尽管再生障碍持续时间短暂且无潜在血液系统疾病，但10%的死亡率似乎与这些中毒患者对内源性继发性感染（主要源于肠道）的易感性有关。
