Suppr超能文献

肾移植中的输尿管并发症与尿路重建技术:一篇外科论述

Ureteric Complications and Urinary Tract Reconstruction Techniques in Renal Transplantation: A Surgical Essay.

作者信息

Novacescu Dorin, Abol-Enein Hassan, Latcu Silviu, Zara Flavia, Secasan Cosmin-Ciprian, Barbos Vlad, Pasecinic Victor, Musta Mihael, Albarakaty Ahmad Mohammed, Bakhsh Abdulaziz, Ismail Hossam, Cumpanas Alin Adrian

机构信息

Department II of Microscopic Morphology, Victor Babes University of Medicine and Pharmacy Timisoara, E. Murgu Square, No. 2, 300041 Timisoara, Romania.

Urology Department, Urology and Nephrology Center, Mansoura University, Mansoura 35516, Egypt.

出版信息

J Clin Med. 2025 Jun 11;14(12):4129. doi: 10.3390/jcm14124129.

Abstract

: Renal transplantation (RT) remains the gold standard for end-stage renal disease, offering superior outcomes versus dialysis. Despite advances, ureteric complications (leaks/strictures) persist, primarily from ischemic injury, posing substantial graft risks. We review etiology, incidence, and management strategies for post-RT ureteric complications, focusing on surgical reconstruction techniques. : Literature assessment examined ischemic-related ureteric complications. Primary outcomes: incidence, success, complication rates, operative times, and long-term patency. Secondary outcomes: graft/patient survival and reoperation rates. Techniques evaluated included extravesical Lich-Gregoir (L-G) and transvesical Leadbetter-Politano (L-P) ureteroneocystostomy (UNC), Boari flap with psoas hitch, pyelo/ureteroureterostomy, pyelovesicostomy, and ureteroenterostomy. Surgical indications, procedural details, advantages, disadvantages, and quantitative outcomes were systematically analyzed. : Ureteric complication incidence ranged from 1 to 15%, with ischemic injury as the primary cause. L-G UNC demonstrated lower complication rates than L-P (6.15% vs. 8.33%) with reduced operative times. Pyelo/ureteroureterostomy achieved excellent salvage outcomes (>90% success, 3.9% reintervention rate). Boari flap provides a suitable option for extensive ureteric defects, consistently preserving graft function without stricture recurrences. Pyelovesicostomy showed 80% long-term success in complex cases. Ureteroenterostomy achieved comparable 5-year graft survival (63%) to standard drainage, despite higher infection rates (65%). Pyelovesicostomy and ureteroenterostomy remain important solutions for specific challenging scenarios. : Urinary reconstruction technique selection should be individualized based on anatomical considerations, pathology, and surgical expertise. Comprehensive understanding of reconstruction techniques enables effective management of ureteric complications, preserving graft function and improving outcomes.

摘要

肾移植(RT)仍然是终末期肾病的金标准,与透析相比疗效更佳。尽管取得了进展,但输尿管并发症(渗漏/狭窄)仍然存在,主要是由于缺血性损伤,给移植肾带来了巨大风险。我们回顾了肾移植术后输尿管并发症的病因、发生率及处理策略,重点关注手术重建技术。:文献评估研究了与缺血相关的输尿管并发症。主要观察指标:发生率、成功率、并发症发生率、手术时间及长期通畅率。次要观察指标:移植肾/患者生存率及再次手术率。评估的技术包括膀胱外Lich-Gregoir(L-G)和经膀胱Leadbetter-Politano(L-P)输尿管膀胱吻合术(UNC)、带腰大肌悬吊的Boari瓣、肾盂/输尿管输尿管吻合术、肾盂膀胱吻合术及输尿管肠吻合术。系统分析了手术适应证、手术细节、优缺点及量化结果。:输尿管并发症发生率为1%至15%,缺血性损伤是主要原因。L-G UNC的并发症发生率低于L-P(6.15%对8.33%),手术时间缩短。肾盂/输尿管输尿管吻合术取得了出色的挽救效果(成功率>90%,再次干预率3.9%)。Boari瓣为广泛的输尿管缺损提供了合适的选择,能持续保留移植肾功能且无狭窄复发。肾盂膀胱吻合术在复杂病例中显示出80%的长期成功率。输尿管肠吻合术尽管感染率较高(65%),但5年移植肾生存率与标准引流相当(63%)。肾盂膀胱吻合术和输尿管肠吻合术仍然是特定挑战性情况的重要解决方案。:应根据解剖学因素、病理情况及手术专业知识对尿路重建技术进行个体化选择。全面了解重建技术有助于有效处理输尿管并发症,保留移植肾功能并改善治疗效果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee32/12193927/f81603a4ae13/jcm-14-04129-g001.jpg

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验