Blumberg Yair, de Monts Constance, Montalvo Samuel, Tang Whitney J, Dunaway Young Sally, Hageman Nathan, Sanchis-Gomar Fabian, Ashley Euan A, Amar David, Myers Jonathan, Wheeler Matthew T, Day John W, Duong Tina, Christle Jeffrey W
Division of Cardiovascular Medicine, Department of Medicine, Stanford University, Stanford, CA 94305, USA.
Division of Neurology and Neurological Sciences, Department of Medicine, Stanford University, Stanford, CA 94305, USA.
J Clin Med. 2025 Jun 12;14(12):4190. doi: 10.3390/jcm14124190.
Individuals with neuromuscular diseases (NMDs) have low physical activity levels and an increased risk of cardiovascular and pulmonary diseases. Respiratory gas kinetics obtained during cardiopulmonary exercise testing (CPET) may provide valuable insights into disease mechanisms and cardiorespiratory fitness in individuals with NMD. Recovery from exercise is an important marker of exercise performance and overall physical health, and impaired recovery is strongly associated with poor health outcomes. This study evaluates recovery metrics in individuals with NMD after performing maximal exertion during CPET. A total of 34 individuals with NMD and 15 healthy volunteers were recruited for the study. CPET was performed using a wearable metabolic system and a wheelchair-accessible total body trainer to peak exertion. Recovery metrics assessed were (i) the time to reach 50% O recovery compared with peak exercise and (ii) the ratios of ventilation and respiratory gases between peak exercise and the highest values observed during recovery (overshoot). The NMD group had a significantly longer time to reach 50% O recovery (T1/2 VO: 105 ± 43.4 vs. 76 ± 36.4 s, = 0.02), lower respiratory overshoot (17.1 ± 13.0% vs. 28.8 ± 9.03%), and lower ventilation/VO (31.9 ± 28.3 vs. 52.2 ± 23.5) compared to the control group. This study observes significantly impaired recovery metrics following peak exercise in individuals with NMD compared to controls. These insights may improve the understanding of exercise recovery and mechanics, thus improving prognostication and optimizing exercise prescriptions for individuals with NMD.
患有神经肌肉疾病（NMDs）的个体身体活动水平较低，患心血管和肺部疾病的风险增加。在心肺运动试验（CPET）期间获得的呼吸气体动力学可能为NMD个体的疾病机制和心肺健康提供有价值的见解。运动恢复是运动表现和整体身体健康的重要指标，恢复受损与不良健康结果密切相关。本研究评估了NMD个体在CPET期间进行最大运动后的恢复指标。共有34名NMD个体和15名健康志愿者被招募参加该研究。使用可穿戴代谢系统和可通过轮椅进入的全身训练器进行CPET，直至达到最大运动强度。评估的恢复指标包括：（i）与运动峰值相比达到50%氧恢复的时间；（ii）运动峰值与恢复期间观察到的最高值之间的通气和呼吸气体比率（过冲）。与对照组相比，NMD组达到50%氧恢复的时间显著更长（T1/2 VO：105±43.4秒对76±36.4秒，P = 0.02），呼吸过冲更低（17.1±13.0%对28.8±9.03%），通气/VO更低（31.9±28.3对52.2±23.5）。本研究观察到，与对照组相比，NMD个体在运动峰值后恢复指标明显受损。这些见解可能会增进对运动恢复和机制的理解，从而改善对NMD个体的预后评估并优化运动处方。
