Yoon Hye-Jin, Park Keon-Woo, Seo Young-Hoon
Dunsan Endocrinology Medical Clinic, Daejeon 35230, Republic of Korea.
Department of Internal Medicine, Konyang University Hospital, Daejeon 35365, Republic of Korea.
J Clin Med. 2025 Jun 12;14(12):4191. doi: 10.3390/jcm14124191.
The clinical implications of sarcopenia and visceral obesity in patients with cardiovascular disease (CVD) are poorly understood. We evaluated the impact of sarcopenia and visceral obesity on clinical outcomes among older adults with CVD. This retrospective cohort study included patients aged 65 years and older who had cardiovascular disease and had undergone body composition analysis using dual-energy X-ray absorptiometry (DXA) between November 2021 and October 2022 and been followed through February 2024. Sarcopenia was defined using the 2019 Asian Working Group for Sarcopenia criteria, and visceral obesity was defined using Korean sex-specific visceral adipose tissue area. The primary outcome was a composite of all-cause mortality and major cardiovascular events, including myocardial infarction, stroke, hospitalization for heart failure, and coronary revascularization. This study followed the Strengthening the Reporting of Observational Studies in Epidemiology reporting guidelines. A total of 317 patients were included, of whom 118 patients (37.2%) had sarcopenia, 184 (58.0%) had visceral obesity, and 55 (17.4%) had sarcopenic obesity. The prevalence of sarcopenia or visceral obesity was 93.8% in patients with obesity and 69.3% in those without obesity. Sarcopenic obesity showed a mixture of characteristics of two metabolic conditions in terms of demographics and body mass index. Sarcopenia was associated with an increased risk of primary outcomes (hazard ratio [HR], 1.93; 95% CI, 1.02-3.66), with the highest risk observed in patients with sarcopenic obesity (HR, 6.74; 95% CI, 1.81-25.16). Sarcopenia was associated with 1.9-fold increased risk of cardiovascular events among older adults with CVD, with a greater than 6-fold increased risk when combined with visceral obesity.
肌肉减少症和内脏肥胖症在心血管疾病(CVD)患者中的临床意义尚不清楚。我们评估了肌肉减少症和内脏肥胖症对老年CVD患者临床结局的影响。这项回顾性队列研究纳入了65岁及以上患有心血管疾病的患者,这些患者在2021年11月至2022年10月期间接受了双能X线吸收法(DXA)进行的身体成分分析,并随访至2024年2月。肌肉减少症采用2019年亚洲肌肉减少症工作组标准进行定义,内脏肥胖症采用韩国特定性别的内脏脂肪组织面积进行定义。主要结局是全因死亡率和主要心血管事件的综合指标,包括心肌梗死、中风、因心力衰竭住院和冠状动脉血运重建。本研究遵循了《加强流行病学观察性研究报告规范》的报告指南。共纳入317例患者,其中118例(37.2%)患有肌肉减少症,184例(58.0%)患有内脏肥胖症,55例(17.4%)患有肌肉减少性肥胖症。肥胖患者中肌肉减少症或内脏肥胖症的患病率为93.8%,非肥胖患者中为69.3%。在人口统计学和体重指数方面,肌肉减少性肥胖症表现出两种代谢状况的混合特征。肌肉减少症与主要结局风险增加相关(风险比[HR],1.93;95%可信区间[CI],1.02 - 3.66),在肌肉减少性肥胖症患者中风险最高(HR,6.74;95%CI,1.81 - 25.16)。肌肉减少症与老年CVD患者心血管事件风险增加1.9倍相关,与内脏肥胖症合并时风险增加超过6倍。