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将暴露组学整合到对认知衰老和痴呆症的生命历程理解中：当前证据、方法学挑战及未来方向

Integrating Exposome into Lifecourse Understanding of Cognitive Ageing and Dementia: Current Evidence, Methodological Challenges, and Future Directions.

作者信息

Gong Jessica, Zaninotto Paola

机构信息

Department of Epidemiology and Public Health, University College London, London WC1E 7HB, UK.

George Institute for Global Health, Imperial College London, London W12 7RZ, UK.

出版信息

Int J Environ Res Public Health. 2025 May 22;22(6):815. doi: 10.3390/ijerph22060815.

DOI:10.3390/ijerph22060815
PMID:40566243
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12193384/
Abstract

Cognitive decline and dementia represent some of the most pressing challenges to global public health, especially amid rapidly ageing populations worldwide [...].

摘要

认知能力下降和痴呆症是全球公共卫生面临的一些最紧迫挑战，尤其是在全球人口迅速老龄化的背景下[...]。

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本文引用的文献

1
Integrating exposomics into biomedicine.将暴露组学整合到生物医学中。
Science. 2025 Apr 25;388(6745):356-358. doi: 10.1126/science.adr0544. Epub 2025 Apr 24.
2
Unraveling the role of proteins in dementia: insights from two UK cohorts with causal evidence.揭示蛋白质在痴呆症中的作用：来自两个具有因果证据的英国队列研究的见解。
Brain Commun. 2025 Mar 3;7(2):fcaf097. doi: 10.1093/braincomms/fcaf097. eCollection 2025.
3
Proteomic organ-specific ageing signatures and 20-year risk of age-related diseases: the Whitehall II observational cohort study.蛋白质组学器官特异性衰老特征与20年患年龄相关疾病的风险：白厅II队列观察性研究
Lancet Digit Health. 2025 Mar;7(3):e195-e204. doi: 10.1016/j.landig.2025.01.006.
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Integrating the environmental and genetic architectures of aging and mortality.整合衰老与死亡率的环境和遗传结构。
Nat Med. 2025 Mar;31(3):1016-1025. doi: 10.1038/s41591-024-03483-9. Epub 2025 Feb 19.
5
Exposomics: a review of methodologies, applications, and future directions in molecular medicine.暴露组学：分子医学中的方法、应用及未来方向综述
EMBO Mol Med. 2025 Apr;17(4):599-608. doi: 10.1038/s44321-025-00191-w. Epub 2025 Jan 27.
6
Plasma proteomics identify biomarkers and undulating changes of brain aging.血浆蛋白质组学可识别脑衰老的生物标志物及波动变化。
Nat Aging. 2025 Jan;5(1):99-112. doi: 10.1038/s43587-024-00753-6. Epub 2024 Dec 9.
7
Methods in causal inference. Part 2: Interaction, mediation, and time-varying treatments.因果推断方法。第2部分：交互作用、中介作用和随时间变化的治疗方法。
Evol Hum Sci. 2024 Oct 1;6:e41. doi: 10.1017/ehs.2024.32. eCollection 2024.
8
Reconceptualizing and Defining Exposomics within Environmental Health: Expanding the Scope of Health Research.重新概念化和定义环境健康中的暴露组学：扩展健康研究的范围。
Environ Health Perspect. 2024 Sep;132(9):95001. doi: 10.1289/EHP14509. Epub 2024 Sep 27.
9
Brain clocks capture diversity and disparities in aging and dementia across geographically diverse populations.大脑时钟揭示了不同地理区域人群在衰老和痴呆方面的多样性和差异。
Nat Med. 2024 Dec;30(12):3646-3657. doi: 10.1038/s41591-024-03209-x. Epub 2024 Aug 26.
10
Dementia prevention, intervention, and care: 2024 report of the Lancet standing Commission.《痴呆症的预防、干预与照护：柳叶刀常设委员会2024年报告》
Lancet. 2024 Aug 10;404(10452):572-628. doi: 10.1016/S0140-6736(24)01296-0. Epub 2024 Jul 31.