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癌细胞如何产生癌症相关成纤维细胞亚型？细胞外囊泡对基质多样性的影响。

How Do Cancer Cells Create Cancer-Associated Fibroblast Subtypes? Impacts of Extracellular Vesicles on Stromal Diversity.

作者信息

Naito Yutaka

机构信息

Department of Molecular Prevention, Institute for Advanced Medical Sciences, Nippon Medical School, Tokyo, Japan.

Department of Molecular Prevention, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan.

出版信息

Cancer Sci. 2025 Sep;116(9):2347-2361. doi: 10.1111/cas.70133. Epub 2025 Jun 25.

DOI:10.1111/cas.70133
PMID:40566852
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12400057/
Abstract

Cancer-associated fibroblasts (CAFs) are the major component of the tumor stroma. They mediate various attributes of tumor cells, such as cell growth, migration, invasion, angiogenesis, metabolic reprogramming, apoptosis, immune regulation, and extracellular matrix reconstitution, all related to cancer progression and treatment resistance. Although many researchers have recognized CAF heterogeneity, recent technological advances have emphasized the functional and phenotypic diversity of CAFs in cancer progression. Why are these CAF subtypes generated within tumor tissues? And how do cancer cells dictate such heterogeneous subtypes of CAFs? This review will highlight the CAF subtypes within the tumor microenvironment and their role in tumor progression. CAF subtype induction by extracellular vesicles (EVs) and their significance, which we reported previously, is also discussed.

摘要

癌症相关成纤维细胞（CAFs）是肿瘤基质的主要成分。它们介导肿瘤细胞的多种特性，如细胞生长、迁移、侵袭、血管生成、代谢重编程、凋亡、免疫调节和细胞外基质重构，所有这些都与癌症进展和治疗耐药性相关。尽管许多研究人员已经认识到CAF的异质性，但最近的技术进步强调了CAFs在癌症进展中的功能和表型多样性。为什么这些CAF亚型会在肿瘤组织中产生？癌细胞又是如何决定CAFs的这种异质亚型的？本综述将重点介绍肿瘤微环境中的CAF亚型及其在肿瘤进展中的作用。我们之前报道的细胞外囊泡（EVs）诱导CAF亚型及其意义也将进行讨论。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/760b/12400057/d58cdce6052c/CAS-116-2347-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/760b/12400057/237c170490b0/CAS-116-2347-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/760b/12400057/417d243d5325/CAS-116-2347-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/760b/12400057/d58cdce6052c/CAS-116-2347-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/760b/12400057/237c170490b0/CAS-116-2347-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/760b/12400057/417d243d5325/CAS-116-2347-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/760b/12400057/d58cdce6052c/CAS-116-2347-g001.jpg

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本文引用的文献

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Extracellular Vesicles from Lung Adenocarcinoma Cells Induce Activation of Different Cancer-Associated Fibroblast Subtypes.来自肺腺癌细胞的细胞外囊泡可诱导不同癌症相关成纤维细胞亚型的激活。
Biomedicines. 2024 Nov 4;12(11):2523. doi: 10.3390/biomedicines12112523.
2
Cancer-associated fibroblast subtypes modulate the tumor-immune microenvironment and are associated with skin cancer malignancy.癌症相关成纤维细胞亚型调节肿瘤免疫微环境，并与皮肤癌恶性程度相关。
Nat Commun. 2024 Nov 8;15(1):9678. doi: 10.1038/s41467-024-53908-9.
3
Synthetic retinoid-mediated preconditioning of cancer-associated fibroblasts and macrophages improves cancer response to immune checkpoint blockade.
合成维甲酸介导的癌相关成纤维细胞和巨噬细胞预处理可改善癌症对免疫检查点阻断的反应。
Br J Cancer. 2024 Jul;131(2):372-386. doi: 10.1038/s41416-024-02734-3. Epub 2024 Jun 7.
4
Deciphering the spatial landscape and plasticity of immunosuppressive fibroblasts in breast cancer.解析乳腺癌中免疫抑制成纤维细胞的空间景观和可塑性。
Nat Commun. 2024 Apr 1;15(1):2806. doi: 10.1038/s41467-024-47068-z.
5
Distinct fibroblast subpopulations associated with bone, brain or intrapulmonary metastasis in advanced non-small-cell lung cancer.晚期非小细胞肺癌中与骨、脑或肺内转移相关的不同成纤维细胞亚群。
Clin Transl Med. 2024 Mar;14(3):e1605. doi: 10.1002/ctm2.1605.
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Cancer Cell. 2024 Apr 8;42(4):682-700.e12. doi: 10.1016/j.ccell.2024.02.002. Epub 2024 Feb 29.
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J Extracell Vesicles. 2024 Feb;13(2):e12404. doi: 10.1002/jev2.12404.
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