Mechanism of self-protection in a puromycin-producing micro-organism.
作者信息
Sugiyama M, Paik S Y, Nomi R
出版信息
J Gen Microbiol. 1985 Aug;131(8):1999-2005. doi: 10.1099/00221287-131-8-1999.
PMID:4056740
Abstract
Puromycin is a potent inhibitor of bacterial protein synthesis, but puromycin-producing Streptomyces alboniger KCC S-0309 is tolerant to the antibiotic in vivo. Puromycin bound to both 30S and 50S ribosomal subunits from S. alboniger and inhibited polyuridylate-directed polyphenylalanine synthesis by the ribosomes. However, the organism possessed a novel puromycin-inactivating enzyme which acetylated the antibiotic at the 2''-NH2 group of the O-methyltyrosine moiety.
摘要
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