Wang Jin, Yang Huiran, Li Qingjian, Wang Yucen, Zhang Pei, Wang Zhiliang
Department of Cardiology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Department of Ophthalmology, Huashan Hospital, Fudan University, Shanghai, China.
Front Cell Dev Biol. 2025 Jun 3;13:1612303. doi: 10.3389/fcell.2025.1612303. eCollection 2025.
This study employed swept-source optical coherence tomography angiography (SS-OCTA) to explore potential hemodynamic alterations in the retina and choroid following radiofrequency catheter ablation (RFCA) for atrial fibrillation (AF).
A total of 58 eyes from 32 patients were included, with SS-OCTA examinations conducted preoperatively and 1 day postoperatively. The evaluated parameters encompassed vessel density (VD) of the superficial vascular complex (SVC), VD of the deep vascular complex (DVC), choroidal vascular index (CVI), choroidal thickness (CT), thickness of the superficial retinal layer (SRL), and thickness of the deeper retinal layer (DRL).
Results indicated no significant changes in the VD of the SVC and DVC, nor in the thickness of the superficial and deeper retinal layers. Conversely, CT demonstrated a significant increase (P < 0.05) and the CVI exhibited a notable rise exclusively within the 1-mm diameter region centered on the fovea (P < 0.05).
These findings underscore the remarkable hemodynamic stability of retinal microcirculation in the early postoperative phase. The observed increase in CT and localized elevation in CVI may signify compensatory mechanisms involving enhanced postoperative choroidal perfusion and redistribution of cardiac output, thereby reinforcing the choroid's superior sensitivity as a biomarker for detecting subtle hemodynamic shifts in AF-related ocular pathology.
本研究采用扫频光学相干断层扫描血管造影（SS-OCTA）技术，探讨心房颤动（AF）患者行射频导管消融术（RFCA）后视网膜和脉络膜潜在的血流动力学变化。
纳入32例患者的58只眼，术前及术后1天进行SS-OCTA检查。评估参数包括浅表血管复合体（SVC）的血管密度（VD）、深部血管复合体（DVC）的VD、脉络膜血管指数（CVI）、脉络膜厚度（CT）以及浅表视网膜层（SRL）和深层视网膜层（DRL）的厚度。
结果显示，SVC和DVC的VD以及浅表和深层视网膜层的厚度均无显著变化。相反，CT显著增加（P < 0.05），且CVI仅在以黄斑中心凹为中心的直径1毫米区域内显著升高（P < 0.05）。
这些发现强调了术后早期视网膜微循环显著的血流动力学稳定性。观察到的CT增加和CVI局部升高可能表明存在代偿机制，包括术后脉络膜灌注增强和心输出量重新分布，从而强化了脉络膜作为检测AF相关眼部病理中细微血流动力学变化生物标志物的更高敏感性。
