Motamed Shariati Mehrdad, Khazaei Sahel, Yaghoobi Mariye
Eye Research Center, Khatam Al-Anbia Eye Hospital, Mashhad University of Medical Sciences, Gharani Boulevard, Mashhad, Iran.
Int J Retina Vitreous. 2024 Nov 18;10(1):87. doi: 10.1186/s40942-024-00607-8.
The choroid, a highly vascular structure within the eye, is significantly influenced by various systemic conditions. The advent of enhanced depth optical coherence tomography has improved our ability to evaluate choroidal pathophysiology. The choroidal vascularity index (CVI), a noninvasive and reliable tool, serves as an effective means of assessing the choroidal vascular structure. Recent studies have increasingly focused on exploring CVI alterations under different systemic conditions. This study aims to provide a comprehensive summary of the latest research findings in this area.
A systematic literature review was conducted on October 1, 2023, using two databases, MEDLINE (via PubMed) and Scopus. Search terms were tailored specifically for each database to ensure a thorough exploration of relevant literature. The studies identified were qualitatively assessed, with particular emphasis on outcomes related to CVI and choroidal thickness.
A total of 48 studies were included in the review, encompassing a diverse range of systemic conditions such as diabetes, central nervous system disorders, cardiovascular diseases, autoimmune disorders, and infectious diseases. Notable reductions in CVI were observed in diabetic retinopathy, autoimmune diseases, and neurodegenerative disorders. Additionally, the review highlighted variations in CVI values related to the severity of systemic diseases, indicating its potential use as a biomarker for disease progression.
This review highlights the significant correlation between variations in the choroidal vascularity index and diverse systemic conditions affecting hemodynamics. An enhanced understanding of CVI provides deeper insights into the pathophysiological mechanisms underlying these disorders and positions CVI as a promising biomarker for early detection and monitoring. Nevertheless, its clinical utility warrants careful assessment. Future research should address the potential limitations of CVI to fully capitalize on its diagnostic and prognostic potential.
脉络膜是眼内高度血管化的结构，受到各种全身状况的显著影响。增强深度光学相干断层扫描技术的出现提高了我们评估脉络膜病理生理学的能力。脉络膜血管指数（CVI）是一种无创且可靠的工具，是评估脉络膜血管结构的有效手段。最近的研究越来越多地聚焦于探索不同全身状况下CVI的变化。本研究旨在全面总结该领域的最新研究发现。
于2023年10月1日进行了一项系统的文献综述，使用了两个数据库，即MEDLINE（通过PubMed）和Scopus。针对每个数据库专门定制了检索词，以确保全面探索相关文献。对所识别的研究进行了定性评估，特别强调与CVI和脉络膜厚度相关的结果。
该综述共纳入48项研究，涵盖了多种全身状况，如糖尿病、中枢神经系统疾病、心血管疾病、自身免疫性疾病和传染病。在糖尿病视网膜病变、自身免疫性疾病和神经退行性疾病中观察到CVI显著降低。此外，该综述强调了CVI值与全身疾病严重程度相关的变化，表明其作为疾病进展生物标志物的潜在用途。
本综述强调了脉络膜血管指数的变化与影响血流动力学的多种全身状况之间的显著相关性。对CVI的深入理解为这些疾病的病理生理机制提供了更深入的见解，并将CVI定位为早期检测和监测的有前景的生物标志物。然而，其临床实用性值得仔细评估。未来的研究应解决CVI的潜在局限性，以充分利用其诊断和预后潜力。
