Malik Saba R, Salopek Thomas G, Walker John, Gniadecki Robert
Division of Dermatology, University of Alberta, Edmonton, AB, Canada.
Department of Oncology, University of Alberta, Edmonton, AB, Canada.
SAGE Open Med Case Rep. 2025 Jun 24;13:2050313X251350371. doi: 10.1177/2050313X251350371. eCollection 2025.
A 69-year-old male receiving ixekizumab for plaque psoriasis presented with violaceous dermal nodules in a sporotrichoid pattern on the right distal lower leg. Biopsy and imaging led to the diagnosis of stage IIIB Merkel cell carcinoma. Treatment with avelumab, chemotherapy, and radiotherapy led to partial remission, but 4 years later, he succumbed to the disease. Ixekizumab-associated immunosuppression may have contributed to Merkel cell carcinoma development, a tumor known to occur more frequently in immunocompromised individuals.
一名69岁男性因斑块状银屑病接受司库奇尤单抗治疗，右下肢远端出现呈孢子丝菌病样的紫罗兰色皮肤结节。活检和影像学检查确诊为IIIB期默克尔细胞癌。阿维鲁单抗、化疗和放疗治疗后病情部分缓解，但4年后患者死于该病。司库奇尤单抗相关的免疫抑制可能促使了默克尔细胞癌的发生，这种肿瘤在免疫功能低下的个体中更常见。
