Ntemou Effrosyni, Reisch Klara, Burchert Frank, Jonkers Roel, Picht Thomas, Rofes Adrià
Center for Language and Cognition (CLCG), University of Groningen, Groningen, the Netherlands.
Department of Neurosurgery, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Neuroimage Rep. 2023 Sep 21;3(4):100184. doi: 10.1016/j.ynirp.2023.100184. eCollection 2023 Dec.
Patients with left perisylvian gliomas might undergo language mapping with nTMS in preparation for awake brain surgery. Action naming is an important addition to the presurgical language mapping protocol. However, it has not yet been determined whether specific action stimuli can influence mapping outcomes in terms of number and/or localisation of induced errors.
We investigated this question by employing tractography-based nTMS language mapping of the left arcuate fasciculus (AF) with two types of verbs: transitive and intransitive. Data were collected from 22 patients with a left perisylvian glioma.
Our results demonstrated that nTMS induced a higher error rate with transitive rather than intransitive verbs, specifically during stimulation of the posterior temporal terminations of the left AF (transitive error rate: 8.3%; intransitive error rate: 4.8%). The effect was absent when gliomas displaced the temporal terminations of the AF. Also, nTMS triggered a higher number of semantic errors with transitive (vs intransitive) actions during stimulation of the posterior temporal terminations of the AF (semantic error rate - transitives: 3.3%; semantic error rate - intransitives: 0%).
Our work highlights that clinical outcomes of language mapping with nTMS are affected by the choice of linguistic stimuli. Transitive verbs may be suited to achieve optimal nTMS mapping outcomes in posterior temporal areas of the left AF in this population. Displacement of white matter terminations due to the tumor can affect these results, and semantic errors may indicate core language processes that can be mapped when administering transitive verbs.
左侧颞周胶质瘤患者可能会在清醒开颅手术前接受神经导航经颅磁刺激（nTMS）进行语言图谱绘制。动作命名是术前语言图谱绘制方案的重要补充。然而，尚未确定特定的动作刺激是否会在诱发错误的数量和/或定位方面影响图谱绘制结果。
我们通过使用基于纤维束成像的nTMS对左侧弓状束（AF）进行语言图谱绘制，采用及物动词和不及物动词两种类型的动词来研究这个问题。收集了22例左侧颞周胶质瘤患者的数据。
我们的结果表明，nTMS诱发及物动词的错误率高于不及物动词，特别是在刺激左侧AF的颞叶后部终末时（及物动词错误率：8.3%；不及物动词错误率：4.8%）。当胶质瘤移位AF的颞叶终末时，这种效应不存在。此外，在刺激AF的颞叶后部终末时，nTMS诱发及物（相对于不及物）动作的语义错误数量更多（语义错误率 - 及物动词：3.3%；语义错误率 - 不及物动词：0%）。
我们的研究强调，nTMS语言图谱绘制的临床结果受语言刺激选择的影响。在该人群中，及物动词可能适合在左侧AF的颞叶后部区域实现最佳的nTMS图谱绘制结果。肿瘤导致的白质终末移位会影响这些结果，语义错误可能表明在使用及物动词时可绘制的核心语言过程。
