Kornelsen Jennifer, Witges Kelcie, Labus Jennifer, Mayer Emeran A, Bernstein Charles N
University of Manitoba, Department of Radiology, Winnipeg, Manitoba, Canada.
University of Manitoba IBD Clinical and Research Centre, Winnipeg, Manitoba, Canada.
Neuroimage Rep. 2022 May 6;2(2):100097. doi: 10.1016/j.ynirp.2022.100097. eCollection 2022 Jun.
As the importance of the brain-gut axis in the pathobiology of inflammatory bowel disease (IBD) continues to evolve, a greater understanding of brain structure and functional connectivity (FC) is necessary. In this magnetic resonance imaging (MRI) study, we investigated differences in brain structure and in FC of brain regions in 111 participants with IBD (76 ulcerative colitis (UC) and 35 Crohn's disease (CD)) and 74 healthy controls (HC). Significant differences between IBD and HC were observed in the three analyses used (voxel based morphometry, region-of-interest, and independent component analysis) in brain regions of the default mode, cerebellar, and visual networks. Significant differences between IBD subtypes (UC, CD) were found. The results of the current study establish that a relationship between brain functional connectivity and the brain-gut axis exists in IBD.
随着脑-肠轴在炎症性肠病（IBD）病理生物学中的重要性不断演变，有必要更深入地了解脑结构和功能连接（FC）。在这项磁共振成像（MRI）研究中，我们调查了111名IBD患者（76例溃疡性结肠炎（UC）和35例克罗恩病（CD））和74名健康对照者（HC）的脑结构及脑区功能连接的差异。在默认模式、小脑和视觉网络的脑区所采用的三项分析（基于体素的形态学测量、感兴趣区域和独立成分分析）中，观察到IBD患者与健康对照者之间存在显著差异。还发现IBD各亚型（UC、CD）之间存在显著差异。当前研究结果证实，IBD中存在脑功能连接与脑-肠轴之间的关系。
