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用于齿痕舌识别的弱监督多实例主动学习

Weakly supervised multiple-instance active learning for tooth-marked tongue recognition.

作者信息

Deng Feilin, Li Shangxuan, Yang Zizhu, Zhou Wu

机构信息

School of Medical Information Engineering, Guangzhou University of Chinese Medicine, Guangzhou, China.

出版信息

Front Physiol. 2025 Jun 11;16:1598850. doi: 10.3389/fphys.2025.1598850. eCollection 2025.

DOI:10.3389/fphys.2025.1598850
PMID:40568472
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12187592/
Abstract

INTRODUCTION

Recognizing a tooth-marked tongue has important clinical diagnostic value in traditional Chinese medicine. Current deep learning methods for tooth mark detection require extensive manual labeling and tongue segmentation, which is labor-intensive. Therefore, we propose a weakly supervised multipleinstance active learning model for tooth-marked tongue recognition, aiming to eliminate preprocessing segmentation and reduce the annotation workload while maintaining diagnostic accuracy.

METHOD

We propose a one-stage method tongenerate tooth mark instances that eliminates the need for pre-segmentation of the tongue. To make full use of unlabeled data, we introduce a semisupervised learning paradigm to pseudo-label unlabeled tongue images with high model confidence in active learning and incorporate them into the training set to improve the training efficiency of the active learning model. In addition, we propose an instance-level hybrid query method considering the diversity of tooth marks.

RESULT

Experimental results on clinical tongue images verify the effectiveness of the proposed method, which achieves an accuracy of 93.88% for tooth-marked tongue recognition, outperforming the recently introduced weakly supervised approaches.

CONCLUSION

The proposed method is effective with only a small amount of image-level annotation, and its performance is comparable to that of image-level annotation, instance-level annotation and pixel-level annotation, which require a large number of tooth markers. Our method significantly reduces the annotation cost of the binary classification task of traditional Chinese medicine tooth mark recognition.

摘要

引言

在中医中,识别齿痕舌具有重要的临床诊断价值。当前用于齿痕检测的深度学习方法需要大量的人工标注和舌部分割,这是一项劳动密集型工作。因此,我们提出了一种用于齿痕舌识别的弱监督多实例主动学习模型,旨在消除预处理分割并减少标注工作量,同时保持诊断准确性。

方法

我们提出了一种单阶段方法来生成齿痕实例,从而无需对舌头进行预分割。为了充分利用未标注数据,我们引入了一种半监督学习范式,在主动学习中用模型置信度高的伪标签标注未标注的舌图像,并将它们纳入训练集以提高主动学习模型的训练效率。此外,我们提出了一种考虑齿痕多样性的实例级混合查询方法。

结果

在临床舌图像上的实验结果验证了所提方法的有效性,该方法在齿痕舌识别中达到了93.88%的准确率,优于最近引入的弱监督方法。

结论

所提方法仅需少量图像级标注就有效,其性能与需要大量齿痕标注的图像级标注、实例级标注和像素级标注相当。我们的方法显著降低了中医齿痕识别二分类任务的标注成本。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8fb/12187592/861c7f4a3c4d/fphys-16-1598850-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8fb/12187592/e782b38202f3/fphys-16-1598850-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8fb/12187592/a43ca1d8a818/fphys-16-1598850-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8fb/12187592/98358deb364a/fphys-16-1598850-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8fb/12187592/e35e8d2ba68a/fphys-16-1598850-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8fb/12187592/321c644f87dd/fphys-16-1598850-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8fb/12187592/4e9ed934ed5c/fphys-16-1598850-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8fb/12187592/3a3b2798526e/fphys-16-1598850-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8fb/12187592/861c7f4a3c4d/fphys-16-1598850-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8fb/12187592/e782b38202f3/fphys-16-1598850-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8fb/12187592/a43ca1d8a818/fphys-16-1598850-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8fb/12187592/98358deb364a/fphys-16-1598850-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8fb/12187592/e35e8d2ba68a/fphys-16-1598850-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8fb/12187592/321c644f87dd/fphys-16-1598850-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8fb/12187592/4e9ed934ed5c/fphys-16-1598850-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8fb/12187592/3a3b2798526e/fphys-16-1598850-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8fb/12187592/861c7f4a3c4d/fphys-16-1598850-g008.jpg

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本文引用的文献

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Oral_voting_transfer: classification of oral microorganisms' function proteins with voting transfer model.口头投票转移:用投票转移模型对口腔微生物功能蛋白进行分类
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Weakly Supervised Deep Learning for Tooth-Marked Tongue Recognition.用于齿痕舌识别的弱监督深度学习
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Artificial intelligence in tongue diagnosis: Using deep convolutional neural network for recognizing unhealthy tongue with tooth-mark.
人工智能在舌诊中的应用:利用深度卷积神经网络识别齿痕不健康舌象。
Comput Struct Biotechnol J. 2020 Apr 8;18:973-980. doi: 10.1016/j.csbj.2020.04.002. eCollection 2020.
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Tooth-Marked Tongue Recognition Using Multiple Instance Learning and CNN Features.基于多实例学习和卷积神经网络特征的齿痕舌识别
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