Singh Yashbir, Hathaway Quincy A, Farrelly Colleen, Budoff Matthew J, Erickson Bradley, Collins Jeremy D, Blaha Michael J, Leiner Tim, Lopez-Jimenez Francisco, Rozenblit Jennifer, Sarkar Deepa, Carlsson Gunnar
Department of Radiology, Mayo Clinic, Rochester, MN.
Department of Radiology, University of Pennsylvania, Philadelphia, PA.
Mayo Clin Proc Digit Health. 2025 Feb 20;3(2):100199. doi: 10.1016/j.mcpdig.2025.100199. eCollection 2025 Jun.
Plaque build-up in the coronary arteries can restrict blood flow or become unstable and contribute to cardiovascular events. Evaluating these plaques is essential for cardiovascular risk stratification and determining the most appropriate treatment strategies. This review aimed to investigate the potential of topological data analysis (TDA), a novel technique, in assessing coronary atherosclerosis. We perform a narrative review of the emerging TDA field, discussing its basic principles and advantages over traditional methods, which often struggle to capture the intricate patterns and relationships within coronary plaques. Topological data analysis can evaluate coronary atherosclerosis in novel ways using variations in the cover and filtration functions of the algorithm, highlighting new ways to characterize calcified and noncalcified plaques. It also highlights the potential of TDA in enhancing the understanding and management of this complex disease. Despite the challenges and future directions, which need to be addressed, TDA shows potential as a valuable tool in assessing coronary atherosclerosis, specifically in noncalcified plaque detection, possibly surpassing traditional techniques in capturing the disease's intricate patterns. A Pubmed, Google Scholar, Scopus - based literature review was undertaken using the following search terms: .
冠状动脉中的斑块积聚可限制血流或变得不稳定，并导致心血管事件。评估这些斑块对于心血管风险分层和确定最合适的治疗策略至关重要。本综述旨在研究一种新技术——拓扑数据分析（TDA）在评估冠状动脉粥样硬化方面的潜力。我们对新兴的TDA领域进行了叙述性综述，讨论了其基本原理以及相对于传统方法的优势，传统方法往往难以捕捉冠状动脉斑块内复杂的模式和关系。拓扑数据分析可以通过算法的覆盖和过滤函数的变化以新颖的方式评估冠状动脉粥样硬化，突出了表征钙化和非钙化斑块的新方法。它还强调了TDA在增强对这种复杂疾病的理解和管理方面的潜力。尽管存在需要解决的挑战和未来方向，但TDA显示出作为评估冠状动脉粥样硬化的有价值工具的潜力，特别是在非钙化斑块检测方面，在捕捉疾病复杂模式方面可能超越传统技术。使用以下搜索词进行了基于PubMed、谷歌学术、Scopus的文献综述： 。
