Zhou Yuchen, Xu Tao, Zhou Yiyan, Chen Nuo, Wu Zhengchao, Yang Zongze, Yang Changwei, Chen Xiaoqing
Department of Spine Surgery, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, 226001, China.
Department of Orthopedics, Yancheng Dafeng People's Hospital, Yancheng, 224100, China.
Adv Sci (Weinh). 2025 Sep;12(36):e03269. doi: 10.1002/advs.202503269. Epub 2025 Jun 26.
After spinal cord injury (SCI), a mass of myelin debris derived from injured myelin sheath will be consistently generated and induce macrophages to be foam cells. It has been established that myelin debris and foam cells are negative on SCI recovery through direct and indirect neurotoxicity. Different from previous studies, the present research utilized efficient biological composite materials to adsorb myelin debris, exploring new avenues for solving foam cells and myelin debris following SCI. To achieve the strategy, the present author team has developed the biomaterial composed of polycaprolactone (PCL) nanofiber and pretreated macrophage membranes. Results in vitro and in vivo showed that the composite biomaterial effectively adsorbed myelin debris, with a result of few remaining foam cells, mitigated inflammation, minimal scarring, and favorable motor function recovery. Moreover, lipidomics and proteomics, from a metabolic perspective, further demonstrated the regulatory role of the composite biomaterial in myelin debris. Taken together, the composite biomaterial can effectively promote SCI recovery, which provides a novel insight for the treatment of SCI.
脊髓损伤（SCI）后，受损髓鞘会持续产生大量髓鞘碎片，并诱导巨噬细胞转变为泡沫细胞。已有研究表明，髓鞘碎片和泡沫细胞通过直接和间接的神经毒性作用对脊髓损伤的恢复产生负面影响。与以往研究不同的是，本研究采用高效生物复合材料吸附髓鞘碎片，探索解决脊髓损伤后泡沫细胞和髓鞘碎片问题的新途径。为实现这一策略，作者团队研发了由聚己内酯（PCL）纳米纤维和预处理巨噬细胞膜组成的生物材料。体内外实验结果表明，该复合生物材料能有效吸附髓鞘碎片，减少泡沫细胞残留，减轻炎症，减少瘢痕形成，并促进运动功能良好恢复。此外，从代谢角度进行的脂质组学和蛋白质组学研究进一步证明了该复合生物材料对髓鞘碎片的调节作用。综上所述，该复合生物材料能有效促进脊髓损伤的恢复，为脊髓损伤的治疗提供了新的思路。
