Lally K P, Shorr L D, Nichols R L
J Pediatr Surg. 1985 Oct;20(5):541-2. doi: 10.1016/s0022-3468(85)80484-x.
The utility of an adjunctive aminoglycoside lavage in the prevention of intra-abdominal abscesses utilizing an experimental rodent model was studied. Peritonitis was created in 115 rats by the intra-abdominal placement of gelatin capsules containing a barium-sulfate, human stool mixture. Four hours later, the animals were re-explored and lavaged with 30 ml/kg of sterile saline. Following the lavage, they were randomized to receive 15 ml/kg of either a 0.2% gentamicin or a normal saline lavage. The animals were then treated with intramuscular gentamicin-clindamycin or saline placebo for nine days. There was no difference in the number of abscesses between the groups receiving systemic antibiotics. The addition of gentamicin to a peritoneal lavage did not decrease the incidence of intra-abdominal infection in animals receiving effective systemic antibiotics.
利用实验性啮齿动物模型研究了辅助性氨基糖苷类灌洗在预防腹腔内脓肿方面的效用。通过在腹腔内放置含有硫酸钡与人粪便混合物的明胶胶囊，在115只大鼠中诱发腹膜炎。4小时后，再次打开动物腹腔并用30毫升/千克的无菌盐水进行灌洗。灌洗后，将它们随机分为两组，分别接受15毫升/千克的0.2%庆大霉素灌洗或生理盐水灌洗。然后，对动物进行为期九天的肌肉注射庆大霉素-克林霉素或生理盐水安慰剂治疗。接受全身抗生素治疗的两组之间脓肿数量没有差异。在接受有效全身抗生素治疗的动物中，在腹膜灌洗中添加庆大霉素并没有降低腹腔内感染的发生率。
