Prinz R A, Shuber Z, Fareed J, Bird T, Sandberg L
Arch Surg. 1986 Oct;121(10):1173-6. doi: 10.1001/archsurg.1986.01400100081016.
To evaluate the effectiveness of heparin and heparin fractions in decreasing abscess formation, rats were divided into six groups. A fibrin clot containing 10(9) live Escherichia coli was placed in the peritoneal cavity of each rat. Group 1 (controls) received daily subcutaneous (SQ) injections of 0.1 mL of saline solution. Group 2 received daily intramuscular injections of gentamicin, 12.5 mg/kg. Group 3 received a daily SQ dose of 30 U of porcine heparin. In addition to gentamicin, group 4 received heparin, group 5 received heparin fraction PK10169, and group 6 received heparin fraction CY216, all in daily SQ doses of 30 U. Survivors were killed at ten days and examined for intra-abdominal abscesses. All group 1 animals developed abscesses. Abscess formation was significantly decreased in all groups receiving gentamicin. When used with gentamicin, neither heparin nor heparin fractions decreased the number of abscesses formed when compared with gentamicin alone. Heparin or heparin fractions in combination with gentamicin did decrease abscess size significantly when compared with controls.
为评估肝素及肝素片段在减少脓肿形成方面的效果，将大鼠分为六组。在每只大鼠的腹腔内植入含有10⁹ 活大肠杆菌的纤维蛋白凝块。第1组（对照组）每日皮下注射0.1 mL生理盐水。第2组每日肌肉注射庆大霉素，剂量为12.5 mg/kg。第3组每日皮下注射30 U猪肝素。除庆大霉素外，第4组接受肝素，第5组接受肝素片段PK10169，第6组接受肝素片段CY216，所有剂量均为每日皮下注射30 U。在第10天处死存活的大鼠，并检查腹腔内脓肿情况。所有第1组动物均形成脓肿。所有接受庆大霉素治疗的组中脓肿形成均显著减少。与单独使用庆大霉素相比，当与庆大霉素联合使用时，肝素及肝素片段均未减少脓肿形成的数量。与对照组相比，肝素或肝素片段与庆大霉素联合使用确实显著减小了脓肿大小。
