Qvist N, Storm K, Holmskov A
J Perinat Med. 1985;13(4):179-83. doi: 10.1515/jpme.1985.13.4.179.
In a prospective randomized study of 39 consecutive cesarean sections, 20 patients received cimetidine 400 mg intramuscularly as a pre-anesthetic, an 19 control patients were given NaCl. No perinatal effects on the infants were observed by cardiotocography before delivery, and K, Na, pH, PCO2, HCO-3 and glucose values in capillary blood were nearly identical in the two groups 2 hours after birth, the difference being non-significant (p greater than 0.05). No respiratory effects or arrhythmias were observed. In another study comprising 8 elective cesarean sections in patients with uncomplicated pregnancies, cimetidine was found to cross the placenta at a maternal/cord blood ratio of 3:1. The drug could not be detected in any of the infants 2 hours after delivery.
在一项对39例连续剖宫产的前瞻性随机研究中，20例患者在麻醉前接受400mg西咪替丁肌肉注射，19例对照患者给予氯化钠。分娩前通过胎心监护未观察到对婴儿的围产期影响，出生后2小时两组毛细血管血中的钾、钠、pH、PCO₂、HCO₃⁻和葡萄糖值几乎相同，差异无统计学意义（p＞0.05）。未观察到呼吸影响或心律失常。在另一项包括8例无并发症妊娠患者择期剖宫产的研究中，发现西咪替丁以3:1的母体/脐血比例穿过胎盘。分娩后2小时在任何婴儿中均未检测到该药物。
