Finbloom D S, Silver K, Newsome D A, Gunkel R
J Rheumatol. 1985 Aug;12(4):692-4.
We assessed the frequency of retinal toxicity in patients receiving either chloroquine or hydroxychloroquine and factors which may predict patient susceptibility to toxicity. The overall frequency of retinopathy was 6% (7 of 110 patients). Of the 31 patients receiving chloroquine alone, 6 developed toxicity (19%). In contrast, of the 66 patients receiving hydroxychloroquine, none developed retinopathy. Retinopathy was associated with greater age and with greater accumulative doses of chloroquine. Thus, hydroxychloroquine can be used safely with minimal risk of toxicity.
我们评估了接受氯喹或羟氯喹治疗的患者视网膜毒性的发生率以及可能预测患者毒性易感性的因素。视网膜病变的总体发生率为6%（110例患者中有7例）。在仅接受氯喹治疗的31例患者中，6例出现毒性反应（19%）。相比之下，在接受羟氯喹治疗的66例患者中，无人发生视网膜病变。视网膜病变与年龄较大以及氯喹累积剂量较高有关。因此，羟氯喹可以安全使用，毒性风险极小。
