Taliaferro Lanyn P, Brenner David J, Amundson Sally A, Garty Guy, Zhang Yuji, Davies Erika W, Carrier France, Ross Joel R, Cline J Mark, Chao Nelson J
Radiation and Nuclear Countermeasures Program (RNCP), Division of Allergy, Immunology, and Transplantation (DAIT), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Rockville, Maryland.
Center for Radiological Research, Columbia University Irving Medical Center, New York, New York.
Radiat Res. 2025 Jun 27. doi: 10.1667/RADE-24-00275.1.
The Centers for Medical Countermeasures against Radiation Consortium (CMCRC) has provided a strong research foundation for the radiobiology science that will follow. After 20 years, however, the CMCRC will continue to conduct research on preparedness in niche areas of radiobiology and advanced product development, many of which were initiated by the CMCRC. This manuscript offers a review of past and current strategies and advancements in medical countermeasures to address radiation injuries, carried out by the CMCRC and funded by the National Institute of Allergy and Infectious Diseases Radiation and Nuclear Countermeasures Program. It also explores the mechanisms of radiation-induced injuries, discusses existing medical countermeasures, and highlights emerging technologies and potential future directions for radiobiology researchers. This review aims to enhance our understanding of current medical countermeasures against radiation and contribute to the future development of more efficient and innovative approaches to mitigate and treat radiation-induced damage.
辐射医学对策联盟（CMCRC）为后续的放射生物学奠定了坚实的研究基础。然而，20年后，CMCRC将继续在放射生物学的特定领域和先进产品开发方面开展准备工作的研究，其中许多研究是由CMCRC发起的。本手稿回顾了由CMCRC开展并由美国国立过敏与传染病研究所辐射与核对策项目资助的、针对辐射损伤的医学对策的过去和当前策略及进展。它还探讨了辐射致伤机制，讨论了现有的医学对策，并突出了新兴技术以及放射生物学研究人员未来的潜在方向。本综述旨在增进我们对当前辐射医学对策的理解，并为未来开发更高效、创新的方法以减轻和治疗辐射损伤做出贡献。
