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通过热分解法合成的超小镧系氧化物（Ln = Eu、Gd和Tb）纳米粒子的磁共振成像和X射线成像特性

Magnetic Resonance Imaging and X-Ray Imaging Properties of Ultrasmall Lanthanide Oxide (Ln = Eu, Gd, and Tb) Nanoparticles Synthesized via Thermal Decomposition.

作者信息

Liu Shuwen, Tegafaw Tirusew, Ho Son Long, Yue Huan, Zhao Dejun, Liu Ying, Mulugeta Endale, Chen Xiaoran, Lee Hansol, Ahn Dabin, Yang Ji-Ung, Park Ji Ae, Baek Ahrum, Kim Jihyun, Chang Yongmin, Lee Gang Ho

机构信息

Department of Chemistry, College of Natural Sciences, Kyungpook National University, Taegu 41566, Republic of Korea.

Division of Biomedical Science, School of Medicine, Kyungpook National University, Taegu 41944, Republic of Korea.

出版信息

Molecules. 2025 Jun 9;30(12):2519. doi: 10.3390/molecules30122519.

DOI:10.3390/molecules30122519
PMID:40572485
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12196006/
Abstract

Owing to their 4f electrons and high atomic numbers, lanthanide (Ln) elements impart lanthanide oxide (LnO) nanoparticles with excellent biomedical imaging properties. This study reports synthesis for three types of ultrasmall and monodisperse LnO nanoparticles (Ln = Eu, Gd, and Tb) via thermal decomposition in oleylamine at 280 °C, followed by ligand exchange with citric acid (CA) to produce water-dispersible, CA-grafted LnO nanoparticles with high colloidal stability. The resulting CA-grafted LnO nanoparticles had average diameters of approximately 2 nm. We characterized their physicochemical properties, including in vitro cytotoxicity, magnetic resonance imaging properties (i.e., water proton spin relaxivities), and X-ray imaging properties (i.e., X-ray attenuation).

摘要

由于其4f电子和高原子序数，镧系（Ln）元素赋予氧化镧（LnO）纳米颗粒优异的生物医学成像特性。本研究报告了通过在280°C的油胺中热分解合成三种超小且单分散的LnO纳米颗粒（Ln = Eu、Gd和Tb），随后与柠檬酸（CA）进行配体交换，以制备具有高胶体稳定性的水分散性、CA接枝的LnO纳米颗粒。所得的CA接枝的LnO纳米颗粒的平均直径约为2nm。我们表征了它们的物理化学性质，包括体外细胞毒性、磁共振成像特性（即水质子自旋弛豫率）和X射线成像特性（即X射线衰减）。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e9ee/12196006/775c89a0f947/molecules-30-02519-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e9ee/12196006/1146c0d82e69/molecules-30-02519-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e9ee/12196006/2d17b8154dc8/molecules-30-02519-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e9ee/12196006/dec04b7b64bc/molecules-30-02519-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e9ee/12196006/b1d048f8ff86/molecules-30-02519-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e9ee/12196006/2404d0912cf1/molecules-30-02519-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e9ee/12196006/3472c4a501c3/molecules-30-02519-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e9ee/12196006/f2aa450d247e/molecules-30-02519-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e9ee/12196006/e351cfec768a/molecules-30-02519-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e9ee/12196006/775c89a0f947/molecules-30-02519-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e9ee/12196006/1146c0d82e69/molecules-30-02519-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e9ee/12196006/2d17b8154dc8/molecules-30-02519-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e9ee/12196006/dec04b7b64bc/molecules-30-02519-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e9ee/12196006/b1d048f8ff86/molecules-30-02519-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e9ee/12196006/2404d0912cf1/molecules-30-02519-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e9ee/12196006/3472c4a501c3/molecules-30-02519-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e9ee/12196006/f2aa450d247e/molecules-30-02519-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e9ee/12196006/e351cfec768a/molecules-30-02519-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e9ee/12196006/775c89a0f947/molecules-30-02519-g009.jpg

相似文献

[1]
Magnetic Resonance Imaging and X-Ray Imaging Properties of Ultrasmall Lanthanide Oxide (Ln = Eu, Gd, and Tb) Nanoparticles Synthesized via Thermal Decomposition.

Molecules. 2025-6-9

[2]
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[3]
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[7]
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[8]
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[9]
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[10]
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本文引用的文献

[1]
Heavy Metal-Based Nanoparticles as High-Performance X-ray Computed Tomography Contrast Agents.

Pharmaceuticals (Basel). 2023-10-15

[2]
Enhanced Tumor Imaging Using Glucosamine-Conjugated Polyacrylic Acid-Coated Ultrasmall Gadolinium Oxide Nanoparticles in Magnetic Resonance Imaging.

Int J Mol Sci. 2022-2-4

[3]
3D reconstructions, 4D imaging and postprocessing with CT in musculoskeletal disorders: Past, present and future.

Diagn Interv Imaging. 2020-11

[4]
Chemistry of MRI Contrast Agents: Current Challenges and New Frontiers.

Chem Rev. 2018-10-16

[5]
A theranostic nanoplatform: magneto-gold@fluorescence polymer nanoparticles for tumor targeting T&T-MRI/CT/NIR fluorescence imaging and induction of genuine autophagy mediated chemotherapy.

Nanoscale. 2018-5-25

[6]
Inherently Eu /Eu Codoped Sc O Nanoparticles as High-Performance Nanothermometers.

Adv Mater. 2018-2-12

[7]
The role of tannic acid and sodium citrate in the synthesis of silver nanoparticles.

J Nanopart Res. 2017

[8]
Multimodality imaging in nanomedicine and nanotheranostics.

Cancer Biol Med. 2016-9

[9]
Luminescence Enhanced Eu(3+)/Gd(3+) Co-Doped Hydroxyapatite Nanocrystals as Imaging Agents In Vitro and In Vivo.

ACS Appl Mater Interfaces. 2016-4-27

[10]
Synthesis and application of strawberry-like Fe3O4-Au nanoparticles as CT-MR dual-modality contrast agents in accurate detection of the progressive liver disease.

Biomaterials. 2015-2-19

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