Lopez-Santamarina Aroa, Cardelle-Cobas Alejandra, Mondragon Alicia Del Carmen, Cepeda Alberto, Rodriguez Jose A, Miranda Jose Manuel
Department of Analytical Chemistry, Nutrition and Food Science, School of Veterinary Sciences, University of Santiago de Compostela, 27002 Lugo, Spain.
Área Académica de Química, Universidad Autónoma del Estado de Hidalgo, Carr. Pachuca-Tulancingo Km. 4.5, Mineral de la Reforma 42184, Mexico.
Nutrients. 2025 Jun 19;17(12):2047. doi: 10.3390/nu17122047.
: Brown seaweeds, such as , are a promising source of dietary fiber. However, in vivo evidence regarding the effects of intake on the human gut microbiota remains limited. This study aimed to evaluate the impact of daily consumption on the gut microbiota composition and short-chain fatty acid production in overweight adults. : A randomized, double-blind, placebo-controlled trial was conducted in which 10 overweight adult participants consumed 2 g/day of whole for 30 days. Fecal samples were collected before and after the intervention for 16S rRNA sequencing and short-chain fatty acid analysis. Dietary intake was evaluated using a 24 h recall and a 3-day dietary record. Nutritional assessment was performed to determine habitual macronutrient consumption. : Baseline dietary analysis revealed an imbalanced macronutrient profile characterized by high intakes of total and saturated fats and protein, along with low carbohydrate and fiber consumption. In addition, 50% of the participants were obese, and 50% were overweight based on the BMI. Notable changes in the gut microbiota composition were observed after the intervention, including increases in short-chain fatty acid-producing species, such as , , , and . : This study provides the first clinical evidence in humans that whole can beneficially modulate the gut microbiota composition. These results support the potential use of this seaweed as a functional prebiotic ingredient in dietary strategies aimed at enhancing gut health.
褐藻，如 ，是膳食纤维的一个有前景的来源。然而，关于 摄入量对人体肠道微生物群影响的体内证据仍然有限。本研究旨在评估超重成年人每日食用 对肠道微生物群组成和短链脂肪酸产生的影响。
：进行了一项随机、双盲、安慰剂对照试验，10名超重成年参与者连续30天每天食用2克全 。在干预前后收集粪便样本进行16S rRNA测序和短链脂肪酸分析。使用24小时回忆法和3天饮食记录评估饮食摄入量。进行营养评估以确定习惯性常量营养素消耗情况。
：基线饮食分析显示常量营养素分布不均衡，其特征是总脂肪、饱和脂肪和蛋白质摄入量高，而碳水化合物和纤维消耗量低。此外，根据BMI，50%的参与者肥胖，50%超重。干预后观察到肠道微生物群组成有显著变化，包括短链脂肪酸产生菌，如 、 、 和 增加。
：本研究提供了人类首个关于全 可有益调节肠道微生物群组成的临床证据。这些结果支持将这种海藻作为功能性益生元成分用于旨在促进肠道健康的饮食策略的潜在用途。
