Soares Dara da Costa, Lopes Felipe Teixeira, Pereira Neto Gabriel Dos Santos, Santos Luciana Cristina Coelho Pantoja, Lima Aline Cecy Rocha, Botelho Bruno Sarmento, Abreu Isabella Nogueira, Freitas Felipe Bonfim, Ishak Ricardo, Cayres Vallinoto Izaura Maria Vieira, Vallinoto Antonio Carlos Rosário
Laboratory of Virology, Institute of Biological Sciences, Federal University of Pará, Belém 66075-110, Pará, Brazil.
Virology Section, Evandro Chagas Institute, Ananindeua 67030-000, Pará, Brazil.
Viruses. 2025 May 28;17(6):765. doi: 10.3390/v17060765.
This descriptive, observational, cross-sectional study evaluated HTLV-1 and HTLV-2 infections in Ananindeua, northern Brazil. Individuals were screened for anti-HTLV-1/2 using ELISA (Murex HTLV-I + II, DiaSorin). Reactive or indeterminate samples underwent confirmation via Western blot (HTLV Blot 2.4 kit, MP Diagnostics) and/or RT-qPCR. A questionnaire examined behavioral and risk factors for HTLV-1/2 infection. HTLV-positive individuals received counseling, nurse follow-up, and specialized medical care. Among the 228 individuals investigated, 6 (2.7%) were infected with HTLV-1: 4 men (66.67%) and 2 women (33.33%), aged 51-73 years. The only significant risk factor observed was blood transfusion. Additionally, 80 other individuals residing in the municipality of Ananindeua independently visited the laboratory for an HTLV-1/2 diagnosis. Among them, 23 were diagnosed with HTLV-1 infection, and 1 with HTLV-2. Among the 30 positive individuals, 80% were asymptomatic, while 20% exhibited clinical manifestations associated with HTLV infection, including HAM and Sézary syndrome. These results indicate a notable prevalence of HTLV-1 infection in the municipality of Ananindeua emphasizing the significance of diagnosing the infection to assess its prevalence across the country accurately.
这项描述性、观察性横断面研究评估了巴西北部阿纳尼德乌市的人类嗜T淋巴细胞病毒1型（HTLV-1）和人类嗜T淋巴细胞病毒2型（HTLV-2）感染情况。使用酶联免疫吸附测定法（Murex HTLV-I + II，DiaSorin）对个体进行抗HTLV-1/2筛查。反应性或不确定的样本通过蛋白质印迹法（HTLV Blot 2.4试剂盒，MP Diagnostics）和/或逆转录定量聚合酶链反应进行确认。通过问卷调查了解HTLV-1/2感染的行为和风险因素。HTLV阳性个体接受了咨询、护士随访和专业医疗护理。在调查的228名个体中,6人（2.7%）感染了HTLV-1：4名男性（66.67%）和2名女性（33.33%），年龄在51至73岁之间。观察到的唯一显著风险因素是输血。此外，居住在阿纳尼德乌市的80名其他个体独立前往实验室进行HTLV-1/2诊断。其中，23人被诊断为HTLV-1感染，1人被诊断为HTLV-2感染。在这30名阳性个体中，80%无症状，而20%表现出与HTLV感染相关的临床表现，包括热带痉挛性下肢轻瘫和塞扎里综合征。这些结果表明，HTLV-1感染在阿纳尼德乌市的患病率较高，强调了诊断该感染对于准确评估其在全国范围内患病率的重要性。
