1型单纯疱疹病毒与肠道病毒合并感染所致新生儿脑膜炎：病例报告及文献复习

Neonatal Meningitis Due to Herpes Simplex Virus Type 1 and Enterovirus Coinfection: Case Report and Review of the Literature.

作者信息

Coramusi Carolina, Rizzoli Alessandra, Alegiani Caterina, Bonafoni Susanna, Auriti Cinzia, Parisi Pasquale, Scapillati Maria Eleonora

机构信息

Faculty of Medicine and Psychology, Sapienza University, 00185 Rome, Italy.

San Pietro Fatebenefratelli Hospital, Neonatal Intensive Care Unit, Sapienza University, 86100 Rome, Italy.

出版信息

Viruses. 2025 May 30;17(6):790. doi: 10.3390/v17060790.

DOI:10.3390/v17060790

PMID:40573380

Abstract

In the first 90 days, most meningitis cases are viral. Newborns often show nonspecific symptoms, making early diagnosis difficult but crucial for effective treatment and good outcomes. Cerebro-spinal fluid (CSF) analysis is the gold standard for diagnosis, enabling targeted therapy. We report on a newborn with rare viral meningitis due to herpes simplex virus type 1 and enterovirus coinfection. This uncommon situation complicates diagnostic and therapeutic management. We share our experience and review the limited literature on such neonatal viral coinfections.

摘要

在最初的90天里，大多数脑膜炎病例是病毒性的。新生儿通常表现出非特异性症状，这使得早期诊断困难，但对于有效治疗和良好预后至关重要。脑脊液（CSF）分析是诊断的金标准，有助于进行针对性治疗。我们报告了一例因1型单纯疱疹病毒和肠道病毒合并感染导致的罕见病毒性脑膜炎新生儿病例。这种不常见的情况使诊断和治疗管理变得复杂。我们分享我们的经验，并回顾关于此类新生儿病毒合并感染的有限文献。