Yun Chenxi, Yuan Zhe, El Haddaoui-Drissi Rim, Ni Ruitong, Xiao Yunyun, Qi Zhenhui, Shang Jie, Lin Xiao
Key Lab for Space Biosciences and Biotechnology, School of Life Sciences, Northwestern Polytechnical University, Xi'an 710072, China.
Queen Mary University of London Engineering School, Northwestern Polytechnical University, Xi'an 710072, China.
Pharmaceutics. 2025 Jun 8;17(6):757. doi: 10.3390/pharmaceutics17060757.
Every year, millions of people worldwide suffer from bone tissue damage caused by bone trauma and surgical operations, as well as diseases such as osteoporosis, osteoarthritis, osteomyelitis, and periodontitis. Bone defect repair is one of the major challenges in the field of regenerative medicine. Although bone grafts are the gold standard for treating bone defects, factors such as donor sources and immune responses limit their application. Functionalized nanomaterials have become an effective means of treating bone diseases due to their good biocompatibility and osteoinductivity, anti-inflammatory, and antibacterial properties. Metal-organic frameworks (MOFs) are porous coordination polymers composed of metal ions and organic ligands, featuring unique physical properties, including a high surface area-volume ratio and porosity. In regenerative medicine, MOFs function as the functions of drug carriers, metal ion donors, nanozymes, and photosensitizers. When combined with other functional materials, they regulate cellular reactive oxygen species, macrophage phenotypic transformation, bone resorption, osteogenesis, and mineralization, providing a new paradigm for bone tissue engineering. This study reviews the classification of functionalized MOF composites in biomedicine and the application of their synthesis techniques in bone diseases. The unique in vivo and in vitro applications of MOFs in bone diseases, including osteoarthritis, osteoporosis, bone tumors, osteomyelitis, and periodontitis, are explored. Their properties include excellent drug loading and sustained release abilities, high antibacterial activity, and bone induction abilities. This review enables readers to better understand the cutting-edge progress of MOFs in bone regeneration applications, which is crucial for the design of and functional research on MOF-related nanomaterials.
每年，全球数百万人遭受由骨创伤、外科手术以及骨质疏松症、骨关节炎、骨髓炎和牙周炎等疾病导致的骨组织损伤。骨缺损修复是再生医学领域的主要挑战之一。尽管骨移植是治疗骨缺损的金标准，但供体来源和免疫反应等因素限制了它们的应用。功能化纳米材料因其良好的生物相容性、骨诱导性、抗炎和抗菌特性，已成为治疗骨疾病的有效手段。金属有机框架（MOF）是由金属离子和有机配体组成的多孔配位聚合物，具有独特的物理性质，包括高比表面积和孔隙率。在再生医学中，MOF发挥着药物载体、金属离子供体、纳米酶和光敏剂的功能。当与其他功能材料结合时，它们可调节细胞活性氧、巨噬细胞表型转化、骨吸收、骨生成和矿化，为骨组织工程提供了新的范例。本研究综述了生物医学中功能化MOF复合材料的分类及其合成技术在骨疾病中的应用。探讨了MOF在骨疾病（包括骨关节炎、骨质疏松症、骨肿瘤、骨髓炎和牙周炎）中独特的体内和体外应用。它们的特性包括优异的药物负载和缓释能力、高抗菌活性和骨诱导能力。这篇综述使读者能够更好地了解MOF在骨再生应用中的前沿进展，这对于MOF相关纳米材料的设计和功能研究至关重要。
