Hertle L, Garthoff B
J Urol. 1985 Dec;134(6):1251-4. doi: 10.1016/s0022-5347(17)47705-6.
The effects of the calcium channel blocker nisoldipine on renal function after 60 min. normothermic ischemia and contralateral nephrectomy were studied in male Wistar rats. Nisoldipine (300 ppm) was given in a standard diet as well as one hour prior to ischemia (10 mg./kg. orally). Survival, serum urea, serum creatinine, urine volume and creatinine clearance were used to test the effectiveness of the drug. Nisoldipine treatment resulted in the survival of all animals (compared to 66.6 per cent in the untreated group) and improved immediate and long term (14 days) renal function. The drug given post ischemia only was not effective, suggesting that nisoldipine must be present in the kidney during ischemia. The beneficial effects of the drug in postischemic acute renal failure may be attributed in part to effects on postischemic renal hemodynamics. Additional direct effects on ischemic renal epithelial cells, presumably by inhibiting transmembrane calcium fluxes, cannot be excluded.
在雄性Wistar大鼠中研究了钙通道阻滞剂尼索地平对60分钟常温缺血及对侧肾切除术后肾功能的影响。尼索地平（300 ppm）添加于标准饮食中，并在缺血前1小时（口服10 mg/kg）给药。通过存活率、血清尿素、血清肌酐、尿量及肌酐清除率来检测该药物的有效性。尼索地平治疗使所有动物存活（未治疗组的存活率为66.6%），并改善了即刻及长期（14天）肾功能。仅在缺血后给药无效，这表明缺血期间肾脏中必须有尼索地平存在。该药物对缺血后急性肾衰竭的有益作用可能部分归因于对缺血后肾血流动力学的影响。也不能排除其对缺血性肾上皮细胞有额外的直接作用，推测可能是通过抑制跨膜钙通量实现的。
