尼索地平（一种“钙通道阻滞剂”）对大鼠药物诱导的刻板行为的影响。

The influence of nisoldipine--a "calcium entry blocker" on drug induced stereotyped behavior in rats.

作者信息

Shah A B, Poiletman R M, Shah N S

出版信息

Prog Neuropsychopharmacol Biol Psychiatry. 1983;7(2-3):165-73. doi: 10.1016/0278-5846(83)90103-3.

Abstract

In view of potential ability of calcium entry blockers to affect Ca2+ fluxes in neurons, the effects of nisoldipine on phencyclidine (PCP) and apomorphine (APO) induced stereotyped behavior have been examined in 3 and 4 week old rats. The rats (3 and 4 weeks old) were pretreated with either 0.2 ml of saline + ethanol mixture (10:1 v/v) or nisoldipine (25 mg/kg) i.p., 5 min before the i.p. administration of PCP (5 mg/kg) or APO (10 mg/kg). While nisoldipine pretreatment significantly blocked the PCP induced stereotypy in 3 and 4 week old rats, the APO induced stereotypy was not altered. These preliminary data suggest that nisoldipine specifically blocks PCP induced stereotypy probably by antagonizing it effects at the presynaptic level. The significance of this finding in relation to mechanism of action of PCP and calcium entry blockers is discussed.

摘要

鉴于钙通道阻滞剂可能影响神经元中Ca2+通量的能力，已在3周龄和4周龄大鼠中研究了尼索地平对苯环己哌啶（PCP）和阿扑吗啡（APO）诱导的刻板行为的影响。（3周龄和4周龄的）大鼠在腹腔注射PCP（5mg/kg）或APO（10mg/kg）前5分钟，预先腹腔注射0.2ml生理盐水+乙醇混合物（10:1 v/v）或尼索地平（25mg/kg）。虽然尼索地平预处理可显著阻断3周龄和4周龄大鼠中PCP诱导的刻板行为，但APO诱导的刻板行为未改变。这些初步数据表明，尼索地平可能通过在突触前水平拮抗其作用来特异性阻断PCP诱导的刻板行为。讨论了这一发现与PCP和钙通道阻滞剂作用机制的相关性。