Farah Faysal A, Qin Yu, Green Mark A, Wilton-Ely James D E T
Department of Chemistry, Imperial College London, Molecular Sciences Research Hub, White City Campus, London, W12 0BZ, UK.
Department of Physics, King's College London, Strand, London, WC2R 2LS, UK.
Adv Healthc Mater. 2025 Sep;14(24):e2500195. doi: 10.1002/adhm.202500195. Epub 2025 Jun 26.
Semiconducting polymer nanoparticles (SPNs) are a very promising class of fluorescent nanoparticles that exhibit many advantageous optical and biological properties. However, their potential for optical imaging in clinical applications is currently restricted by limited tissue penetration. Multimodal SPN-based contrast agents that integrate several imaging modalities into one platform are able to yield a wealth of information through the use of different imaging mechanisms. The inclusion of magnetic resonance imaging (MRI), with its good spatial resolution and deep tissue penetration, enables SPNs to combine the complementary advantages of MRI and optical imaging. This short review explores the approaches adopted in the literature in the nascent field of multimodal optical-MRI SPN-based probes.
半导体聚合物纳米颗粒（SPNs）是一类非常有前景的荧光纳米颗粒，具有许多有利的光学和生物学特性。然而，它们在临床应用中的光学成像潜力目前受到组织穿透有限的限制。将多种成像方式整合到一个平台的基于SPN的多模态造影剂，能够通过使用不同的成像机制产生大量信息。纳入具有良好空间分辨率和深层组织穿透能力的磁共振成像（MRI），使SPNs能够结合MRI和光学成像的互补优势。这篇简短的综述探讨了文献中在基于SPN的多模态光学-MRI探针这一新兴领域所采用的方法。
