Kitagawa Keita, Ryave Jacob, Sanders Robert A, Lee Ji-Hyun, Zhang Zhongyue, Vilar Saavedra Paulo
Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, Florida, USA.
Department of Small Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, Michigan, USA.
J Vet Intern Med. 2025 Jul-Aug;39(4):e70169. doi: 10.1111/jvim.70169.
The cardiac morphologic and functional derangements induced by doxorubicin (DOX) are referred to as DOX-induced cardiotoxicity (DOX-IC). Prolongation of the QT apex (QTa) has been identified as a potential marker for the early detection of DOX-IC in humans.
Describe changes in QTa that occur in dogs with cancer undergoing DOX monotherapy.
Forty-five client-owned dogs.
Descriptive analysis of data routinely recorded as part of case management of dogs with cancer. Dogs included in the study had a confirmed malignant neoplasm, received DOX as a monotherapy, and had at least 4 ECGs > 30 s. All ECGs included in the study were recorded before DOX administration. Five heartbeats with a stable signal and minimal artifact were randomly selected from each dog, and the QTa was blindly evaluated in lead II, lead III, or both. Subsequently, a linear mixed model was used to quantify the effect of a cumulative dose of DOX on the QTa interval, adjusting for the effect of the other clinical variables.
Forty-five dogs met the inclusion criteria. Among them, 39/45 received five DOX treatments and 26/45 received six DOX treatments. For ECG analysis, 234 ECGs were evaluated for changes in the QTa. The average cumulative dose of DOX was 154.1 mg/m. There was no significant impact of the DOX treatments on the change in QTa (p = 0.8).
Administration of DOX up to a cumulative dose of 154.1 mg/m does not result in QTa prolongation.
阿霉素（DOX）诱导的心脏形态和功能紊乱被称为阿霉素诱导的心脏毒性（DOX-IC）。QT 波峰延长（QTa）已被确定为人类早期检测 DOX-IC 的潜在标志物。
描述接受 DOX 单一疗法的癌症犬 QTa 的变化。
45 只客户拥有的犬。
对作为癌症犬病例管理一部分常规记录的数据进行描述性分析。纳入研究的犬确诊患有恶性肿瘤，接受 DOX 单一疗法，且至少有 4 份心电图记录时长>30 秒。研究中纳入的所有心电图均在给予 DOX 之前记录。从每只犬中随机选择 5 个信号稳定且伪迹最小的心跳，在 II 导联、III 导联或两者上对 QTa 进行盲法评估。随后，使用线性混合模型量化 DOX 累积剂量对 QTa 间期的影响，并对其他临床变量的影响进行校正。
45 只犬符合纳入标准。其中，39/45 接受了 5 次 DOX 治疗，26/45 接受了 6 次 DOX 治疗。对于心电图分析，评估了 234 份心电图的 QTa 变化。DOX 的平均累积剂量为 154.1mg/m。DOX 治疗对 QTa 的变化没有显著影响（p = 0.8）。
给予累积剂量达 154.1mg/m 的 DOX 不会导致 QTa 延长。
