Zhou Kexue, Yang Chengxiang, Li Yan
School of Medicine Chongqing University, Chongqing 400030, China.
Department of Medical Oncology, Chongqing University Cancer Hospital, Chongqing 400030, China.
Cancer Biol Med. 2025 Jun 26;22(6):618-38. doi: 10.20892/j.issn.2095-3941.2025.0066.
Colorectal cancer (CRC) is a common malignant tumor with a high mortality rate worldwide. Advanced CRC often leads to liver metastasis, which has a poor prognosis, highlighting the need to investigate the underlying mechanisms. Omics, encompassing genomics, epigenomics, transcriptomics, proteomics, metabolomics, and microbiomics, enables comprehensive molecular analysis of cells and tissues. Tumor-omics research has advanced rapidly, with growing attention on CRC-related omics. However, systematic reviews on omics research specific to colorectal cancer liver metastasis (CRLM) are limited. This review summarizes the current status and progress of multi-omics research on CRLM and discusses the application of multi-omics technologies in basic research and the significant clinical implications.
结直肠癌（CRC）是一种常见的恶性肿瘤，在全球范围内死亡率很高。晚期结直肠癌常导致肝转移，预后较差，这凸显了研究其潜在机制的必要性。组学包括基因组学、表观基因组学、转录组学、蛋白质组学、代谢组学和微生物组学，能够对细胞和组织进行全面的分子分析。肿瘤组学研究发展迅速，对与结直肠癌相关的组学的关注也日益增加。然而，针对结直肠癌肝转移（CRLM）的组学研究的系统评价有限。本综述总结了CRLM多组学研究的现状和进展，并讨论了多组学技术在基础研究中的应用及其重要的临床意义。
