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结直肠癌肝转移中的多组学：应用与研究进展

Multi-omics in colorectal cancer liver metastasis: applications and research advances.

作者信息

Zhou Kexue, Yang Chengxiang, Li Yan

机构信息

School of Medicine Chongqing University, Chongqing 400030, China.

Department of Medical Oncology, Chongqing University Cancer Hospital, Chongqing 400030, China.

出版信息

Cancer Biol Med. 2025 Jun 26;22(6):618-38. doi: 10.20892/j.issn.2095-3941.2025.0066.

DOI:10.20892/j.issn.2095-3941.2025.0066
PMID:40574729
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12240200/
Abstract

Colorectal cancer (CRC) is a common malignant tumor with a high mortality rate worldwide. Advanced CRC often leads to liver metastasis, which has a poor prognosis, highlighting the need to investigate the underlying mechanisms. Omics, encompassing genomics, epigenomics, transcriptomics, proteomics, metabolomics, and microbiomics, enables comprehensive molecular analysis of cells and tissues. Tumor-omics research has advanced rapidly, with growing attention on CRC-related omics. However, systematic reviews on omics research specific to colorectal cancer liver metastasis (CRLM) are limited. This review summarizes the current status and progress of multi-omics research on CRLM and discusses the application of multi-omics technologies in basic research and the significant clinical implications.

摘要

结直肠癌（CRC）是一种常见的恶性肿瘤，在全球范围内死亡率很高。晚期结直肠癌常导致肝转移，预后较差，这凸显了研究其潜在机制的必要性。组学包括基因组学、表观基因组学、转录组学、蛋白质组学、代谢组学和微生物组学，能够对细胞和组织进行全面的分子分析。肿瘤组学研究发展迅速，对与结直肠癌相关的组学的关注也日益增加。然而，针对结直肠癌肝转移（CRLM）的组学研究的系统评价有限。本综述总结了CRLM多组学研究的现状和进展，并讨论了多组学技术在基础研究中的应用及其重要的临床意义。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d00/12240200/85ca6868777c/cbm-22-06-618-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d00/12240200/c9cf01e22fef/cbm-22-06-618-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d00/12240200/794c8d86c928/cbm-22-06-618-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d00/12240200/2ad25532bc97/cbm-22-06-618-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d00/12240200/85ca6868777c/cbm-22-06-618-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d00/12240200/c9cf01e22fef/cbm-22-06-618-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d00/12240200/794c8d86c928/cbm-22-06-618-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d00/12240200/2ad25532bc97/cbm-22-06-618-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d00/12240200/85ca6868777c/cbm-22-06-618-g004.jpg

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Multi-omics in colorectal cancer liver metastasis: applications and research advances.

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引用本文的文献

[1]
The dark matter in cancer immunology: beyond the visible- unveiling multiomics pathways to breakthrough therapies.

J Transl Med. 2025-7-22

本文引用的文献

[1]
Nano-Armed Limosilactobacillus reuteri for Enhanced Photo-Immunotherapy and Microbiota Tryptophan Metabolism against Colorectal Cancer.

Adv Sci (Weinh). 2025-2

[2]
Genetic and microenvironmental evolution of colorectal liver metastases under chemotherapy.

Cell Rep Med. 2024-12-17

[3]
Campylobacter jejuni-derived cytolethal distending toxin promotes colorectal cancer metastasis.

Cell Host Microbe. 2024-12-11

[4]
Targeting SLITRK4 Restrains Proliferation and Liver Metastasis in Colorectal Cancer via Regulating PI3K/AKT/NFκB Pathway and Tumor-Associated Macrophage.

Adv Sci (Weinh). 2025-1

[5]
Identification and Verification of Key Genes in Colorectal Cancer Liver Metastases Through Analysis of Single-Cell Sequencing Data and TCGA Data.

Ann Surg Oncol. 2024-12

[6]
Single-cell exome sequencing reveals polyclonal seeding and TRPS1 mutations in colon cancer metastasis.

Signal Transduct Target Ther. 2024-9-23

[7]
Proteogenomic Characterization of Early Intrahepatic Recurrence after Curative-Intent Treatment of Colorectal Liver Metastases.

J Proteome Res. 2024-10-4

[8]
High CIB1 expression in colorectal cancer liver metastases correlates with worse survival and the replacement histopathological growth pattern.

Mol Ther Oncol. 2024-6-9

[9]
Genome-wide CRISPR screening identifies the pivotal role of ANKRD42 in colorectal cancer metastasis through EMT regulation.

IUBMB Life. 2024-10

[10]
Investigating the Cell Origin and Liver Metastasis Factors of Colorectal Cancer by Single-Cell Transcriptome Analysis.

Onco Targets Ther. 2024-4-17

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