Zhou Tong, Ma Hui, Li Zhikang, Xu Yijun, Zhao Lingling
Wuhan Kindstar Zhenyuan Medical Laboratory Co., Ltd., Wuhan, China.
Chest Hospital, Tianjin University, Tianjin, China.
Front Oncol. 2025 Jun 12;15:1599608. doi: 10.3389/fonc.2025.1599608. eCollection 2025.
Lung cancer is the most prevalent and deadly malignant tumor in the world. Traditional treatment methods rely on histopathological analysis of cancer cells obtained through tissue biopsies, which carry risks due to their invasive nature. Thus, there is an urgent need to identify effective and non-invasive early screening methods for lung cancer. Exosomes, a crucial element of liquid biopsies, have emerged as a promising alternative due to their non-invasive collection, convenience and cost-effectiveness in diagnosing lung cancer. Research has underscored the role of exosomes in lung cancer invasion, metastasis, immune regulation, and the tumor microenvironment. Furthermore, the contents of exosomes, such as miRNAs, lncRNAs, circRNAs, and proteins, demonstrate considerable potential for the early diagnosis of lung cancer. This article provides a comprehensive review of the role and application of exosomes as liquid biopsy markers for early diagnosis of lung cancer, emphasizing their promise in improving patient outcomes through earlier detection and intervention.
肺癌是全球最常见且致命的恶性肿瘤。传统治疗方法依赖于通过组织活检获取的癌细胞的组织病理学分析，因其具有侵入性而存在风险。因此，迫切需要确定有效的非侵入性肺癌早期筛查方法。外泌体作为液体活检的关键要素，因其在肺癌诊断中具有非侵入性采集、便利性和成本效益等优势，已成为一种有前景的替代方法。研究强调了外泌体在肺癌侵袭、转移、免疫调节和肿瘤微环境中的作用。此外，外泌体的内容物，如微小RNA（miRNAs）、长链非编码RNA（lncRNAs）、环状RNA（circRNAs）和蛋白质，在肺癌早期诊断方面具有巨大潜力。本文全面综述了外泌体作为液体活检标志物在肺癌早期诊断中的作用和应用，强调了其通过早期检测和干预改善患者预后的前景。
