Smirnova Olga V, Sinyakov Aleksander, Kasparov Edward V
Laboratory of Clinical Pathophysiology, Federal Research Center "Krasnoyarsk Scientific Center of the Siberian Branch of the Russian Academy of Sciences", Separate Subdivision Research Institute for Medical Problems of the North, Krasnoyarsk 660022, Russia.
World J Gastroenterol. 2025 Jun 21;31(23):106538. doi: 10.3748/wjg.v31.i23.106538.
The problem of ulcerative colitis (UC) is becoming increasingly relevant due to its prevalence and combination with psychological disorders. UC is associated with alterations in the intestinal microbiocenosis as one of the factors reducing tolerance to self-antigens. In addition, patients with UC often experience anxiety, depression and other negative emotional and psychological factors aggravating the course of the underlying disease. The study presented by Wang shows that the traditional Chinese medicine Wuling can exert its therapeutic effect by reversing the aberrant precursor of brain-derived neurotrophic factor (BDNF)/ BDNF signaling in mice with UC and depression. The combination of Wuling powder with mesalazine can exhibit an antidepressant effect and reduce intestinal inflammation. Undoubtedly, the study by Chinese authors deserves attention, and changes in the balance of precursor of BDNF/p75 neurotrophin receptor/sortilin and BDNF/tropomyosin receptor kinase B signaling may become a novel therapeutic target for clinical treatment and further development of research.
由于溃疡性结肠炎（UC）的患病率及其与心理障碍的合并存在，该疾病问题变得越来越重要。UC与肠道微生物群落的改变有关，这是降低对自身抗原耐受性的因素之一。此外，UC患者经常经历焦虑、抑郁和其他负面情绪及心理因素，这些因素会加重基础疾病的病程。王等人发表的研究表明，中药五灵可以通过逆转UC和抑郁症小鼠中脑源性神经营养因子（BDNF）/BDNF信号通路的异常前体来发挥其治疗作用。五灵散与美沙拉嗪联合使用可发挥抗抑郁作用并减轻肠道炎症。毫无疑问，中国作者的这项研究值得关注，BDNF/p75神经营养因子受体/排序素前体与BDNF/原肌球蛋白受体激酶B信号通路平衡的变化可能成为临床治疗和进一步研究发展的新治疗靶点。
