Huda Md Nazmul, Haque Md Obaidul, Urme Nadia Afrin, Halder Polok
Department of Physiotherapy, Centre for Rehabilitation of the Paralyzed, Savar, Dhaka, Bangladesh.
Department of Physiotherapy, Bangladesh Health Professions Institute, Savar, Dhaka, Bangladesh.
BMJ Open Sport Exerc Med. 2025 Jun 24;11(2):e002735. doi: 10.1136/bmjsem-2025-002735. eCollection 2025.
Osteoarthritis (OA) is a common degenerative condition primarily affecting the knee joint. OA is defined as the gradual degradation of the cartilage in the joints, accompanied by changes in the bone underlying the cartilage, the synovial fluid, the ligaments and the muscles around the affected area. Common manifestations of OA include sensations of pain, stiffness and decreased physical movement. The estimated worldwide incidence of OA is 16.0%. The treatment known as mobilisation with movement (MWM) reduces pain and restores a full range of motion in the affected joint. This study will be a randomised, single-blind controlled trial. 50 adult patients diagnosed with knee OA will be recruited. Participants will be randomly assigned to receive either MWM or conventional physiotherapy treatment. Outcome measures will include the Numerical Pain Rating Scale for assessing pain intensity, a goniometer for measuring joint range of motion, and the Western Ontario and McMaster Universities Osteoarthritis Index for evaluating functional status. Assessments will be conducted at baseline (pretest) and after the intervention (post-test). The Institutional Review Board of the Bangladesh Health Professions Institute has approved the study. Every participant will give their informed consent, and only authorised people will have access to the anonymised data. The study results will be presented at conferences and in peer-reviewed journals. Trial registration number: CTRI/2025/05/086343.
骨关节炎（OA）是一种常见的退行性疾病，主要影响膝关节。OA的定义为关节软骨的逐渐退化，同时伴有软骨下骨、滑液、韧带以及患区周围肌肉的变化。OA的常见表现包括疼痛、僵硬以及身体活动减少。据估计，OA在全球的发病率为16.0%。一种名为运动疗法（MWM）的治疗方法可减轻疼痛并恢复患关节的全范围活动。本研究将是一项随机、单盲对照试验。将招募50名被诊断为膝关节OA的成年患者。参与者将被随机分配接受MWM或传统物理治疗。结果测量将包括用于评估疼痛强度的数字疼痛评分量表、用于测量关节活动范围的量角器以及用于评估功能状态的西安大略和麦克马斯特大学骨关节炎指数。评估将在基线（预测试）和干预后（后测试）进行。孟加拉国卫生专业人员研究所的机构审查委员会已批准该研究。每位参与者都将给予知情同意，并且只有授权人员才能访问匿名数据。研究结果将在会议上和同行评审期刊上发表。试验注册号：CTRI/2025/05/086343。
