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微生物组、生态失调与益生菌在各种疾病中的应用

Microbiome, dysbiosis and use of probiotics in various diseases.

作者信息

Tüsüz Önata Ece, Özdemir Öner

机构信息

Division of Allergy and Immunology, Department of Pediatrics, Sakarya Research and Training Hospital, Sakarya University, Faculty of Medicine, Sakarya 54100, Türkiye.

出版信息

World J Virol. 2025 Jun 25;14(2):99574. doi: 10.5501/wjv.v14.i2.99574.

DOI:10.5501/wjv.v14.i2.99574
PMID:40575647
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12188878/
Abstract

The community of microorganisms that colonize certain areas of the human body is called microbiota. Microorganisms such as bacteria, fungi and viruses make up the microbiota. The sum of the genomes of these microorganisms and microorganisms refers to the microbiome. It has been shown that microbiota has important effects such as protecting the organ from pathogens, contributing to metabolic functions (such as vitamin synthesis, carbohydrate digestion) and providing immunoregulation. Dysbiosis refers to compositional and functional changes in the microbiota. At the beginning of the 21 century, numerous studies have investigated the human microbiota and its imbalance in relation to various diseases and found that dysbiosis is associated with many diseases. The aim of this mini-review article is to provide brief information about dysbiosis and its care and to raise awareness.

摘要

定植于人体特定部位的微生物群落被称为微生物群。细菌、真菌和病毒等微生物构成了微生物群。这些微生物的基因组总和被称为微生物组。研究表明,微生物群具有重要作用,如保护器官免受病原体侵害、促进代谢功能(如维生素合成、碳水化合物消化)以及提供免疫调节。生态失调是指微生物群的组成和功能发生变化。在21世纪初,众多研究调查了人类微生物群及其与各种疾病相关的失衡情况,并发现生态失调与许多疾病有关。这篇小型综述文章的目的是提供有关生态失调及其护理的简要信息并提高认识。

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Nutrients. 2024 Apr 9;16(8):1100. doi: 10.3390/nu16081100.
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Role of Intestinal Microbes in Chronic Liver Diseases.肠道微生物在慢性肝病中的作用。
Int J Mol Sci. 2022 Oct 21;23(20):12661. doi: 10.3390/ijms232012661.
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Gut microbiota, inflammatory bowel disease and colorectal cancer.肠道微生物群、炎症性肠病和结直肠癌。
World J Gastroenterol. 2022 Aug 14;28(30):4053-4060. doi: 10.3748/wjg.v28.i30.4053.
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A Meta-Analysis of Probiotics for the Treatment of Allergic Airway Diseases in Children and Adolescents.益生菌治疗儿童和青少年过敏性气道疾病的荟萃分析。
Am J Rhinol Allergy. 2022 Jul;36(4):480-490. doi: 10.1177/19458924221080159. Epub 2022 Mar 3.
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Gut dysbiosis, defective autophagy and altered immune responses in neurodegenerative diseases: Tales of a vicious cycle.神经退行性疾病中的肠道菌群失调、自噬缺陷与免疫反应改变:恶性循环的故事
Pharmacol Ther. 2022 Mar;231:107988. doi: 10.1016/j.pharmthera.2021.107988. Epub 2021 Sep 16.
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Human gut microbiota/microbiome in health and diseases: a review.人类肠道微生物组/微生物群在健康和疾病中的作用:综述。
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