Cherkasov N S, Tomyshev A S, Lebedeva I S, Abdullina E G, Bozhko O V, Gavrilova S I, Kolykhalov I V
Centre for Mental Health Research, Moscow, Russia.
Zh Nevrol Psikhiatr Im S S Korsakova. 2025;125(6):112-119. doi: 10.17116/jnevro2025125061112.
To determine the structural features of the brain in elderly patients with amnestic syndrome of mild cognitive decline (aMCI) and to identify correlations of these features with mild behavioral disorders.
Fifty-three patients with aMCI (age 73.0±8.5 years, 9 males) and 34 mentally healthy subjects (66.8±9.6 years, 4 males) were examined. Cognitive status was assessed according to the Montreal Cognitive Assessment (MoCA) scale, and the severity of mild behavioral impairment was assessed according to the Mild Behavioral Impairment Checklist (MBI-C). Structural MRI images were obtained using a 3T Philips Ingenia. Cortical gray matter thickness, volumes of subcortical structures, and their correlation with MBI-C and MoCA scores were analyzed.
In patients with aMCI, a smaller cortical thickness was found in the left superior frontal gyrus and right precuneus (0.05), as well as negative correlations of these indicators with MBI-C scores. Also, this group showed smaller volumes of the amygdala and hippocampus of the left hemisphere (0.05) and a positive correlation between the volume of the left amygdala and MoCA scores.
The identified changes in structural MRI indicators and their correlation with neuropsychiatric and neurocognitive symptoms reflect the complex nature of the brain substrate of cognitive and behavioral impairment in aMCI. The results indicate the need for further search for clinically significant phenotypes in patients with aMCI, including those associated with an increased risk of Alzheimer's disease.
确定轻度认知功能下降遗忘综合征（aMCI）老年患者大脑的结构特征，并确定这些特征与轻度行为障碍之间的相关性。
对53例aMCI患者（年龄73.0±8.5岁，男性9例）和34名精神健康受试者（年龄66.8±9.6岁，男性4例）进行检查。根据蒙特利尔认知评估（MoCA）量表评估认知状态，根据轻度行为障碍检查表（MBI-C）评估轻度行为损害的严重程度。使用3T飞利浦Ingenia获取结构MRI图像。分析皮质灰质厚度、皮质下结构体积及其与MBI-C和MoCA评分的相关性。
在aMCI患者中，左侧额上回和右侧楔前叶的皮质厚度较小（P<0.05），并且这些指标与MBI-C评分呈负相关。此外，该组患者左侧半球杏仁核和海马体积较小（P<0.05），左侧杏仁核体积与MoCA评分呈正相关。
结构MRI指标的上述变化及其与神经精神和神经认知症状的相关性反映了aMCI认知和行为损害脑基质的复杂性。结果表明需要进一步寻找aMCI患者具有临床意义的表型，包括那些与阿尔茨海默病风险增加相关的表型。
