Sagirov A M, Romakov A Iu, Sumarokov A B, Mazur N A
Kardiologiia. 1985 Jul;25(7):81-5.
The effect of propranolol-finoptin combinations was examined in 27 patients with angina of effort. Repeated exercise testing showed this combination to provide an essential antianginal effect that exceeded a mere sum of individual effects of each of the two drugs taken alone in the same doses. The high anti-anginal effect of the combination is suggestive of a synergy in their antianginal action resulting in a further reduction of myocardial oxygen requirement. Side effects necessitating discontinuation of the drugs were only recorded during the early days of the treatment; therefore, patients should be adequately monitored during the first days of the regular use of this combination.
对27例劳力性心绞痛患者研究了普萘洛尔与心得安联合用药的效果。反复进行运动试验表明，这种联合用药具有显著的抗心绞痛作用，其效果超过了两种药物同等剂量单独使用时各自效果的简单相加。联合用药的高抗心绞痛效果提示它们在抗心绞痛作用方面具有协同作用，从而进一步降低心肌需氧量。仅在治疗初期记录到有因副作用而停药的情况；因此，在常规使用这种联合用药的头几天应对患者进行充分监测。
