Holenova Katerina, Odatzoglou Petros, Taylor Frances
Wear Referrals, Bradbury, Stockton-on-Tees, UK.
The Queen's Veterinary School Hospital, Department of Veterinary Medicine, University of Cambridge, Cambridge, UK.
J Feline Med Surg. 2025 Jun;27(6):1098612X251338641. doi: 10.1177/1098612X251338641. Epub 2025 Jun 27.
ObjectivesThe current standard-of-care treatment for feline gastrointestinal intermediate- or large-cell lymphoma is systemic chemotherapy. There is some evidence that feline lymphoma patients with a solitary gastrointestinal mass may benefit from excisional surgery followed by chemotherapy; however, most studies of feline gastrointestinal lymphoma combine various stages and anatomical sites of the disease. Studies indicating different behaviour of feline gastrointestinal lymphoma depending on its anatomical location have been published, and significantly longer survival times have been seen in canine colorectal lymphoma. The aim of the present study was therefore to describe the signalment, treatment and outcome of cats with intermediate- or large-cell lymphoma in the colorectal region.MethodsThe medical records of three veterinary hospitals were retrospectively searched for cats diagnosed with a colorectal intermediate- or large-cell lymphoma. The data were collected and subjected to a univariate analysis, and median values were calculated for each of the variables of interest. Median survival times were estimated using the Kaplan-Meier method.ResultsA total of 11 cats were included in the study, with the most common presenting signs being haematochezia, hyporexia, diarrhoea and weight loss. Different treatment strategies and their combinations were used, leading to an overall median survival time of 177 days, with a difference seen between chemotherapy only (29 days) and a combination of surgery and chemotherapy (972 days). Two cats treated with both surgery and chemotherapy were alive at more than 20 months after diagnosis.Conclusions and relevanceThis is the first study to describe specifically cases of cats with intermediate- to large-cell colorectal lymphoma. Even though the number of cases was limited because of the rarity of the disease, the data indicate multimodal treatment might be beneficial in these cases.
目的
猫胃肠道中或大细胞淋巴瘤目前的标准治疗方法是全身化疗。有证据表明，患有孤立性胃肠道肿块的猫淋巴瘤患者可能从切除手术后的化疗中获益；然而，大多数猫胃肠道淋巴瘤的研究将疾病的各个阶段和解剖部位合并在一起。已经发表了表明猫胃肠道淋巴瘤根据其解剖位置表现出不同行为的研究，并且在犬结肠直肠癌淋巴瘤中观察到显著更长的生存时间。因此，本研究的目的是描述结肠直肠区域患有中或大细胞淋巴瘤的猫的特征、治疗方法和结果。
方法
对三家兽医医院的病历进行回顾性检索，以查找诊断为结肠直肠中或大细胞淋巴瘤的猫。收集数据并进行单变量分析，计算每个感兴趣变量的中位数。使用Kaplan-Meier方法估计中位生存时间。
结果
共有11只猫纳入研究，最常见的临床表现为便血、食欲减退、腹泻和体重减轻。采用了不同的治疗策略及其组合，总体中位生存时间为177天，单纯化疗（29天）和手术与化疗联合（972天）之间存在差异。两只接受手术和化疗的猫在诊断后20多个月仍存活。
结论及相关性
这是第一项专门描述结肠直肠中至大细胞淋巴瘤猫病例的研究。尽管由于该疾病罕见，病例数量有限，但数据表明多模式治疗在这些病例中可能有益。
