Xu Shilin, Hu Baoping, Zhang Dongfeng, Wang Jing, He Xue, He Yongjun, Wang Yuhe
Department of Clinical Laboratory, The Affiliated Hospital of Xizang Minzu University, Xianyang, China.
Department of Anesthesia, The Affiliated Hospital of Xizang Minzu University, Xianyang, China.
Ann Med. 2025 Dec;57(1):2523557. doi: 10.1080/07853890.2025.2523557. Epub 2025 Jun 28.
Pulmonary tuberculosis (PTB) remains a significant global health issue, with genetic factors playing a crucial role in susceptibility. Long noncoding RNA (lncRNA) has been implicated in immune responses and cancer, but its association with PTB risk has not been fully explored.
Genomic DNA was extracted from peripheral blood samples of 955 participants (474 PTB cases and 481 controls). Rs12518552 and rs2950218 in were genotyped using the Agena MassARRAY system. Logistic regression analysis was performed to assess the association between these polymorphisms and PTB risk. Stratified analysis was conducted to evaluate the influence of age, gender, and smoking status.
Rs12518552-G (OR = 0.82, = 0.034) and rs2950218-T (OR = 0.77, = 0.012) were associated with a reduced PTB risk. Stratified analysis revealed that rs12518552 was associated with a protective effect against PTB in individuals over 40 years old (OR = 0.73, = 0.024), females (OR = 0.77, = 0.034), and non-smokers (OR = 0.78, = 0.040), and rs2950218 was also associated with a reduced PTB risk in individuals over 40 years old (OR = 0.73, = 0.040), females (OR = 0.72, = 0.046), and non-smokers (OR = 0.72, = 0.011).
polymorphisms, particularly rs12518552 and rs2950218, are associated with a reduced risk of PTB. These findings suggest that C5orf64 polymorphisms contribute to genetic susceptibility to PTB, with implications for PTB targeted screening and personalized therapeutic strategies.
肺结核（PTB）仍然是一个重大的全球健康问题，遗传因素在易感性方面起着关键作用。长链非编码RNA（lncRNA）已被证明与免疫反应和癌症有关，但其与PTB风险的关联尚未得到充分探索。
从955名参与者（474例PTB病例和481名对照）的外周血样本中提取基因组DNA。使用Agena MassARRAY系统对C5orf64中的Rs12518552和rs2950218进行基因分型。进行逻辑回归分析以评估这些多态性与PTB风险之间的关联。进行分层分析以评估年龄、性别和吸烟状况的影响。
Rs12518552-G（OR = 0.82，P = 0.034）和rs2950218-T（OR = 0.77，P = 0.012）与PTB风险降低相关。分层分析显示，Rs12518552在40岁以上个体（OR = 0.73，P = 0.024）、女性（OR = 0.77，P = 0.034）和非吸烟者（OR = 0.78，P = 0.040）中与预防PTB的保护作用相关，并且rs2950218在40岁以上个体（OR = 0.73，P = 0.040）、女性（OR = 0.72，P = 0.046）和非吸烟者（OR = 0.72，P = 0.011）中也与PTB风险降低相关。
C5orf64多态性，特别是Rs12518552和rs2950218，与PTB风险降低相关。这些发现表明C5orf64多态性有助于PTB的遗传易感性，对PTB靶向筛查和个性化治疗策略具有重要意义。
