Kotey Stephen K, Tan Xuejuan, Kinser Audrey L, Liu Lin, Cheng Yong
Department of Biochemistry and Molecular Biology, Oklahoma State University, Stillwater, OK 74078, USA.
Oklahoma Center for Respiratory and Infectious Diseases, Oklahoma State University, Stillwater, OK 74078, USA.
Microorganisms. 2024 Dec 21;12(12):2656. doi: 10.3390/microorganisms12122656.
Mycobacterial infections, caused by various species within the Mycobacterium genus, remain one of the main challenges to global health across the world. Understanding the complex interplay between the host and mycobacterial pathogens is essential for developing effective diagnostic and therapeutic strategies. Host long noncoding RNAs (lncRNAs) have emerged as key regulators in cellular response to bacterial infections within host cells. This review provides an overview of the intricate relationship between mycobacterial infections and host lncRNAs in the context of and non-tuberculous mycobacterium (NTM) infections. Accumulation of evidence indicates that host lncRNAs play a critical role in regulating cellular response to mycobacterial infection within host cells, such as macrophages, the primary host cells for mycobacterial intracellular survival. The expression of specific host lncRNAs has been implicated in the pathogenesis of mycobacterial infections, providing potential targets for the development of novel host-directed therapies and biomarkers for TB diagnosis. In summary, this review aims to highlight the current state of knowledge regarding the involvement of host lncRNAs in mycobacterial infections. It also emphasizes their potential application as novel diagnostic biomarkers and therapeutic targets.
由分枝杆菌属内的各种菌种引起的分枝杆菌感染，仍然是全球公共卫生面临的主要挑战之一。了解宿主与分枝杆菌病原体之间复杂的相互作用，对于制定有效的诊断和治疗策略至关重要。宿主长链非编码RNA（lncRNAs）已成为宿主细胞对细菌感染的细胞反应中的关键调节因子。本综述概述了在结核分枝杆菌和非结核分枝杆菌（NTM）感染的背景下，分枝杆菌感染与宿主lncRNAs之间的复杂关系。越来越多的证据表明，宿主lncRNAs在调节宿主细胞（如巨噬细胞，分枝杆菌细胞内存活的主要宿主细胞）对分枝杆菌感染的细胞反应中起关键作用。特定宿主lncRNAs的表达与分枝杆菌感染的发病机制有关，为新型宿主导向疗法的开发和结核病诊断的生物标志物提供了潜在靶点。总之，本综述旨在突出关于宿主lncRNAs参与分枝杆菌感染的当前知识状态。它还强调了它们作为新型诊断生物标志物和治疗靶点的潜在应用。
