Kong Yi, Yang Xin, Zhou Shuo, Zhou Pengfei, Juhasz Albert, Su Guanyong, Zhang Qian, Cui Xinyi
State Key Laboratory of Water Pollution and Green Resource Recycling, School of the Environment, Nanjing University, Nanjing 210023, People's Republic of China.
Future Industries Institute, University of South Australia, Mawson Lakes, Adelaide, South Australia 5095, Australia.
Environ Sci Technol. 2025 Jul 15;59(27):13683-13692. doi: 10.1021/acs.est.5c04078. Epub 2025 Jun 28.
Liquid crystal monomers (LCMs), widely detected in indoor dust at elevated levels, have been scarcely investigated for their relative bioavailability (RBA) via oral exposure. This study classified 35 typical LCMs into three groups based on structure, namely, fluorinated LCMs (Group A, without ether or nitrile groups), cyanated LCMs (Group B, with nitrile functional groups), and others with ether bonds or unsubstituted benzene rings (Group C). For the distribution in mice, LCMs predominantly accumulated in adipose tissue, with mean concentrations of 502 ng g (Group A) > 159 ng g (Group B) ≈ 147 ng g (Group C). All 35 LCMs were detectable in feces, with a log of 9 as a critical threshold distinguishing gradual versus rapid excretion. Nine stable, frequently detected LCMs were selected for RBA assessment in indoor dust using adipose tissue as the biological end point. The RBA of the 9 LCMs in dust ranged from 8.32 to 108%, highlighting that assuming 100% bioavailability would overestimate the exposure risk of LCMs in dust. A significantly negative correlation ( < 0.01) was found between the total organic carbon (TOC) content of dust and RBA, likely due to the strong adsorption of LCMs by TOC.
液晶单体（LCMs）在室内灰尘中被广泛检测到且含量较高，但对于其经口暴露的相对生物利用度（RBA）却鲜有研究。本研究根据结构将35种典型的LCMs分为三组，即氟化LCMs（A组，无醚基或腈基）、氰化LCMs（B组，有腈官能团）以及其他带有醚键或未取代苯环的LCMs（C组）。在小鼠体内的分布情况中，LCMs主要积聚在脂肪组织中，平均浓度为502 ng/g（A组）> 159 ng/g（B组）≈ 147 ng/g（C组）。所有35种LCMs在粪便中均可检测到，以log 9作为区分逐渐排泄与快速排泄的临界阈值。选择9种稳定且经常检测到的LCMs，以脂肪组织作为生物学终点来评估室内灰尘中的RBA。灰尘中这9种LCMs的RBA范围为8.32%至108%，这突出表明假设生物利用度为100%会高估灰尘中LCMs的暴露风险。发现灰尘中的总有机碳（TOC）含量与RBA之间存在显著负相关（< 0.01），这可能是由于TOC对LCMs有强烈的吸附作用。
