Sadeghi Soheila, Homaee Sina, Samsami Majid, Ebadi Alireza, Saberian Farnaz
Department of Internal Medicine, School of Medicine, Imam Hossein Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Department of Internal Medicine Ward, Chronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Int J Surg Case Rep. 2025 Aug;133:111485. doi: 10.1016/j.ijscr.2025.111485. Epub 2025 Jun 13.
Giant parathyroid adenoma is a rare presentation of parathyroid adenoma and can manifest only with neck mass or non-specific symptoms.
In this report, a 43-year-old woman was referred to our clinic with polyuria two months ago and a neck mass with newly diagnosed stage hypertension. No additional clinical presentations were found. The laboratory study revealed hyperparathyroidism (Parathyroid hormone (PTH): 1124 pg/ml) and hypercalcemia (15.8 mg/dl).
Color Doppler sonography showed a 32 × 15 × 20 mm well-defined hypoechoic solid mass in the region of the thyroid. Following this finding, a parathyroid sestamibi scan was performed as a complementary imaging modality to confirm the diagnosis of parathyroid adenoma, suspected due to elevated levels of PTH and calcium, and to accurately localize the lesion for surgical planning. The scintigraphy confirmed the presence of a giant parathyroid adenoma.
The patient underwent unblock resection of the involved parathyroid and after recovery, she was discharged in good condition. Giant parathyroid adenoma is rare and in patients with nonspecific symptoms, physicians should consider giant parathyroid adenoma in their differential diagnosis process even without common clinical manifestations of hyperparathyroidism.
巨大甲状旁腺腺瘤是甲状旁腺腺瘤的一种罕见表现,可能仅表现为颈部肿块或非特异性症状。
在本报告中,一名43岁女性两个月前因多尿以及伴有新诊断的高血压而前来我院就诊。未发现其他临床表现。实验室检查显示甲状旁腺功能亢进(甲状旁腺激素(PTH):1124 pg/ml)和高钙血症(15.8 mg/dl)。
彩色多普勒超声显示甲状腺区域有一个32×15×20 mm边界清晰的低回声实性肿块。基于这一发现,进行了甲状旁腺99mTc -甲氧基异丁基异腈扫描作为补充成像手段,以确认因PTH和钙水平升高而怀疑的甲状旁腺腺瘤诊断,并准确对病变进行定位以便制定手术方案。闪烁扫描证实存在巨大甲状旁腺腺瘤。
患者接受了患侧甲状旁腺切除术,术后恢复良好,出院时情况良好。巨大甲状旁腺腺瘤较为罕见,对于有非特异性症状的患者,即使没有甲状旁腺功能亢进的常见临床表现,医生在鉴别诊断过程中也应考虑巨大甲状旁腺腺瘤。