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巨大纵隔甲状旁腺腺瘤表现为双侧下颌骨棕色瘤:原发性甲状旁腺功能亢进症的罕见表现

Giant mediastinal parathyroid adenoma presenting as bilateral brown tumour of mandible: a rare presentation of primary hyperparathyroidism.

作者信息

Talukder Shibojit, Behera Arunanshu, Bhadada Sanjay K, Mitra Suvradeep

机构信息

Department of Surgery, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

Department of Endocrinology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

出版信息

BMJ Case Rep. 2017 Oct 23;2017:bcr-2017-220722. doi: 10.1136/bcr-2017-220722.

Abstract

Hyperparathyroidism (HPT) is becoming increasingly common endocrinopathy in clinical practice. Nowadays, it is mostly diagnosed in subclinical or early clinical stage. Bony involvement in HPT has seen significant fall in incidence. Brown tumour of bone is exceptionally rare as a first manifestation of primary HPT (PHPT). Its radiological and histopathological features may be mistaken for other bony pathologies. If possibility of underlying HPT is overlooked the disease is bound to recur after surgery adding to morbidity of the patient. Here we present a case of bilateral brown tumour of mandible which was mistakenly treated as giant cell granuloma by surgical curettage. That the patient was harbouring an ectopic parathyroid adenoma with hypercalcemia causing non-specific symptoms was missed by the referring physician. This led to recurrence of the lesion. On subsequent evaluation, a giant mediastinal parathyroid adenoma causing PHPT was detected at our centre and was removed via mini sternotomy approach.

摘要

甲状旁腺功能亢进症(HPT)在临床实践中已成为越来越常见的内分泌疾病。如今,它大多在亚临床或临床早期阶段被诊断出来。HPT患者的骨受累发病率已显著下降。骨棕色瘤作为原发性甲状旁腺功能亢进症(PHPT)的首发表现极为罕见。其放射学和组织病理学特征可能会被误诊为其他骨病。如果忽视了潜在HPT的可能性,那么该疾病在手术后必然会复发,从而增加患者的发病率。在此,我们报告一例双侧下颌骨棕色瘤病例,并通过手术刮除术将其误诊为巨细胞肉芽肿。转诊医生未发现患者患有导致高钙血症并引起非特异性症状的异位甲状旁腺腺瘤,这导致了病变的复发。在后续评估中,我们中心检测到一例导致PHPT的巨大纵隔甲状旁腺腺瘤,并通过胸骨下段小切口入路将其切除。

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本文引用的文献

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Mediastinal parathyroid adenomas and their surgical implications.纵隔甲状旁腺腺瘤及其手术意义。
Ann R Coll Surg Engl. 2015 May;97(4):259-61. doi: 10.1308/003588415X14181254789088.
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Ectopic parathyroid glands and their anatomical, clinical and surgical implications.异位甲状旁腺及其解剖学、临床和手术学意义。
Exp Clin Endocrinol Diabetes. 2012 Nov;120(10):604-10. doi: 10.1055/s-0032-1327628. Epub 2012 Nov 22.
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Giant anterior mediastinal parathyroid adenoma.巨大的前纵隔甲状旁腺腺瘤。
Clin Nucl Med. 2012 Sep;37(9):889-91. doi: 10.1097/RLU.0b013e31825ae8b6.

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