Eleven undescribed bisabolane-type sesquiterpenoids from Artemisia persica.

Eleven previously undescribed bisabolane-type sesquiterpenoids were successfully isolated from Artemisia persica. The structures of these compounds were comprehensively elucidated through a combination of advanced spectroscopic techniques, including one-dimensional and two-dimensional nuclear magnetic resonance, high-resolution electrospray ionization mass spectrometry, and ultraviolet spectroscopy. Structural assignments were further confirmed by comparison of experimental and time-dependent density functional theory-calculated electronic circular dichroism spectra, as well as single-crystal X-ray diffraction analysis where applicable. To assess their pharmacological relevance, the isolated sesquiterpenoids were subjected to in vitro evaluation of anti-inflammatory activity and cytotoxic potential. Compounds 6 and 9 demonstrated limited anti-inflammatory activity in the lipopolysaccharide-induced inflammation model using RAW 264.7 mouse macrophages, with IC values of 111.1 ± 4.66 μM and 247.8 ± 1.49 μM, respectively.